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0:00
Welcome to this
introductory talk
on general pharmacology.
I'm Karel Allegaert.
I'm a clinical pharmacologist
located at KU Leuven,
which is in Belgium,
as well as in Erasmus
Medical Center,
which is in the Netherlands.
0:18
Why are we covering this topic?
Simply because drugs are
a crucial part of proven,
effective interventions to
improve patient health outcomes
and healthcare efficiency,
while individual responses
to medicine may vary,
related to medicine and
patient-specific characteristics.
That's all about PK and PD.
From a health equity
point of view
and an outcome-relevant
disease point of view,
I can only provide
you some examples,
like, for instance, the
recent COVID vaccinations,
treatments for acute leukemia,
or novel treatments for
spinal muscular atrophy
or cystic fibrosis,
to illustrate the impact
of effective pharmacological
interventions.
1:06
What will we cover
in these lectures?
Well, we will cover,
obviously, pharmacokinetics,
and because of the volume,
we have split this
up into two parts.
The first part is
focusing on absorption,
bioavailability,
and distribution,
while the second part has
its focus on metabolism,
excretion, and the
therapeutic window.
We will discuss routes
of administration,
drug formulation,
pharmacokinetic and
pharmacodynamic integration,
and then a specific focus
on pharmacogenetics
and drug toxicity,
including some
mechanisms, interactions,
and adverse drug reactions.
In the pharmacokinetics,
