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Welcome to the short lecture on drug formulations. I'm Karel Allegaert. I'm a clinical pharmacologist working at KU Leuven; and happy to introduce you to this topic.
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Why would we bother about this topic? It's because different formulations will result in different exposure time profiles and related to that, potential effects or side effects. For specific details on that, I refer to the short lecture on pharmacokinetics. If you compare IV formulations, or intravenous formulations, to oral formulations or to other routes, it's quite obvious that related to absorption, the pattern of a concentration over time will change. But even within an oral formulation, you could compare a slow release versus a general or a common standard formulation. Formulations contain also other compounds besides what we consider the drug (active compounds). This may have to do with excipients, may have to do with taste masking, or may have to do with preservatives. Excipients are commonly used to improve the solubility of a formulation, taste masking is all about palatability, and preservatives, obviously, will improve the shelf life of a given drug. Selection of a formulation should, obviously, be based on patient preferences and needs. It may have to do with age or with disease-related characteristics. For instance, swallowing issues. Then finally, I would like to highlight extemporaneous formulations, as this is still commonly used for specific needs.

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