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0:00
Welcome on the short lecture
on pharmacokinetic
pharmacodynamic integration.
I'm Karel Allegaert.
I'm a clinical
pharmacologist working at
Rotterdam University as
well as at KU Leuven.
0:15
Why are we considering
this topic within this
series of short courses?
Well it's simply because
pharmacokinetics,
describe the concentration
time profile.
In essence, what the
body does to the drug,
but at least as interesting are
pharmacodynamics
as they describe
the concentration
effect profile,
so what the drug
does to the body.
In essence while pharmacokinetics
obviously matter,
we do administer drugs to attain
given effects preferably
without too much side effects,
so we have to integrate
the basic findings
on pharmacokinetics
to pharmacodynamics,
and that's what we will
discuss in this short course.
0:59
Related to the pharmacokinetics,
I refer to previous short
lectures who focus on
absorption distribution
in one lecture
and metabolism and excretion
in the second lecture.
As already alluded to,
we do administer drug to attain
effects preferably
without side effects, so
pharmacokinetics matter
but pharmacodynamics are
the reasons why we administer
drugs to patients.
1:27
How does this work? How can
a drug results in
a given effect?
We will discuss
aspects related to
molecular mechanisms and targets
involved in pharmacodynamics,
and they can refer to
receptors, channels,
proteins, enzymes or any
intracellular targets.
There are different
types of aspects
involved in the extent
and the sensitivity of
these mechanisms and
targets expressed
by affinity and
allosteric modulation.
We will come back on that.
The second aspect will relate to
system pharmacodynamics
because aspects like
desensitization tolerance
and/or tachyphylaxis are
important to be aware of as
prescribing or
administering drugs.
The dose-effect curve is
a commonly used
curve to use what
we call the effective
dose and 50%,
the toxic dose or
even the lethal dose.
It's all about therapeutic index
or the therapeutic range.
Finally, we will
illustrate that sometimes
pharmacokinetics are
disconnected somehow
from pharmacodynamics,
using vitamin K,
proton pump inhibitors,
and acetylsalicylic acid
as illustrations of this.
