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Rare clinical presentations of cerebral amyloid angiopathy

Published on September 30, 2024   15 min

Other Talks in the Series: Cerebral Amyloid Angiopathy (CAA)

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Hi everyone. I'm Nicolas Raposo. I'm a stroke neurologist and coordinator of Stroke Research Program on CAA and Cerebral Small Vessel Diseases at Toulouse University Hospital in France. The topic of my presentation is rare clinical presentations of CAA.
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Here are my disclosures, which are not related to the present topic except for research grants.
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Cerebral amyloid angiopathy, designated as CAA during this talk, is a common age-related cerebral small vessel disease characterized by a beta-amyloid deposition within the wall of small cortical and leptomeningeal vessels.
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This amyloid deposition may lead to various forms of cerebral vascular dysfunction, including blood-brain barrier disruption, impaired cerebrovascular reactivity, impaired perivascular drainage. There's also various forms of brain injury including hemorrhagic damages, this includes lobar intracerebral hemorrhage, microbleeds, convexity subarachnoid hemorrhage, cortical superficial siderosis. May include ischemic injury, such as white matter hyperintensities, small acute ischemic lesions, and cortical micro-infarcts, and also perivascular inflammations. These various forms of brain injury may account for various clinical presentations including stroke symptoms, transient focal neurological episodes, seizures, encephalopathy, cognitive impairment, and dementia.

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Rare clinical presentations of cerebral amyloid angiopathy

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