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0:00
Welcome to this short lecture on
Routes of Drug Administration.
I'm Karel Allegaert, clinical
pharmacologist working both
at KU Leuven in
Belgium as well as
Erasmus University of
Rotterdam, the Netherlands.
0:16
You could question why
we cover this topic.
This is simply because various
routes of administration
will result in different
exposure time profiles
for a given drug.
A commonly used abbreviation
to quantify this is
the F reflecting
either absolute or
relative bioavailability.
We will come back to this
definition in the next slide.
Furthermore, there are
also different formulation
even if the same route of
administration is drawn,
for instance, a
slow release versus
a regular tablet or a
syrup versus a tablet.
These various routes of
administration all have
their advantages
and disadvantages.
Like for instance
invasiveness, easiness,
dose flexibility, or
formulation-related issues.
Finally, the selection of
the route of
administration should be
based on patient preferences
and therapeutic benefits.
Like for instance, do
you want an easy peak
or is sustained exposure
more preferable?
1:21
Bioavailability is by definition
the fraction of an
administered drug that gains
access to the systemic
circulation after
absorption in a chemically
unchanged form.
By definition it
is between 0-100%.
When we consider absolute
bioavailability,
we will compare a
given route versus
the intravenous
administration like
for instance oral to IV
or inhalation to IV while
the relative bioavailability
will express the area under
the curve between two non intravenous
administered formulations
like for instance
oral to inhalation.
