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0:00
Hello. My name is
Dr. Martin Goldberg.
I'm a lecturer in
Clinical Microbiology at
Birmingham City University
One of my great passions
is about antibiotics
and antibiotic resistance and
the development of new
antimicrobial compounds.
So, what today's talk will
be about is first of all
giving you an understanding
of the basics of what
antibiotics are,
how they work, and then looking
onto problems of
antibiotic resistance.
0:38
So, I'll talk about the basic
types of antimicrobial agents.
I'll give you a little
bit of history.
I'm going to then talk
about the semantics
to how it is that compounds are
chosen for therapeutic
use and how clinicians
decide which compounds
are going to be the
most effective depending
on the types of infection.
I'll then give you a
very brief overview
on resistance mechanisms,
mechanisms for the spread
of antibiotic resistance,
looking at the
consequences of resistance
to antimicrobial compounds,
and then finally, an outlook on
the future in terms of
antibiotic resistance
and drug discovery.
1:20
So, there's a few
references here one or
two a little bit elderly, but
nevertheless contain a
few important pieces
of information that
you will find useful.
1:31
First of all, what do we mean
by antimicrobial agents?
These are compounds that inhibit
the growth and/or replication
of microorganisms.
A simple definition
and there are
basically two types of
compounds you can get.
There are bacteriocidal agents
which kill microorganisms
and there are
bacteriostatic or static
agents which rather
than killing the microorganism
simply prevent their growth,
but if the compound is removed
or becomes more dilute,
then growth can recommence.
So, I'm going to give you
a little introduction
