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Common clinical phenotypes in cerebral amyloid angiopathy

Published on October 31, 2023   33 min

Other Talks in the Series: Cerebral Amyloid Angiopathy (CAA)

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0:00
Hello everyone. My name is Marco Pasi. I'm a vascular neurologist working at the University Hospital of Tours, in the neurology department. Today, I will speak about the common clinical phenotype that we can encounter in cerebral amyloid angiopathy (CAA).
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Sporadic CAA can manifest with a widespread range of clinical manifestations. Because CAA has been reported in individuals without 'clear-cut symptoms', in up to 24% of the general population, we can find moderate to severe CAA in pathology reports. Moreover, CAA is consider part of the process, also of normal aging, but in certain cases, CAA can manifest with progressive symptoms, with an insidious clinical course, such as mild cognitive complaints, but cognitive impairment can reach stages of severe dementia. Furthermore, we can also have patients with mild depressive symptoms, but also other neuropsychiatric manifestations, but CAA has also been associated to abrupt and dramatic clinical presentations. This is the case of intracerebral hemorrhage (ICH), especially in elderly people, but also transient focal neurological episodes, also known as the amyloid spell. In this presentation, I will not speak about inflammatory CAA.

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Common clinical phenotypes in cerebral amyloid angiopathy

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