• Design
• 34 min
  1. An introduction to randomization for clinical trials 1

  • Prof. William Rosenberger
• 20 min
  2. An introduction to randomization for clinical trials 2

  • Prof. William Rosenberger
• 42 min
  3. Randomisation, blinding and drug supply in interactive voice response trials

  • Mr. Damian McEntegart
• 42 min
  4. Randomization in clinical trials: time for fresh consideration?

  • Dr. Alex Sverdlov
• Analysis
• 32 min
  5. Design and conduct of non-inferiority trials

  • Prof. Valerie Durkalski-Mauldin
• 37 min
  6. Nonparametric covariate adjustment

  • Prof. Michael Akritas
• 34 min
  7. The impact of randomization on the evidence of a clinical trial

  • Prof. Nicole Heussen
• Theory
• 43 min
  8. Historical and ethical issues in trial design

  • Dr. J. Rosser Matthews
• 52 min
  9. Likelihood ratios and the strength of statistical evidence

  • Prof. Jeffrey Blume
• 36 min
  10. Biomarkers and surrogate endpoints in randomized clinical trials

  • Dr. Marc Buyse
• Randomization, Masking and Allocation Concealment
• 22 min
  11. Detection of and adjustment for selection bias in randomized controlled clinical trials

  • Prof. Lieven Nils Kennes
• 46 min
  12. Innovative and effective subject randomization methods

  • Prof. Wenle Zhao
• 12 min
  13. Selection bias in studies with unequal allocation

  • Dr. Olga M. Kuznetsova
• Archived Lectures *These may not cover the latest advances in the field
• 45 min
  14. Design and conduct of equivalence trials

  • Prof. Valerie Durkalski-Mauldin
• 19 min
  15. Dose-finding trials in oncology

  • Prof. Anastasia Ivanova
• 32 min
  16. Allocation concealment, prediction and selection bias

  • Prof. David Torgerson
• 41 min
  17. Pseudo cluster randomization

  • Dr. George Borm
• 26 min
  18. Introduction to flexible, adaptive trial design

  • Dr. Cyrus Mehta
• 30 min
  19. Randomization in clinical trials

  • Prof. William Rosenberger
• 35 min
  20. Novel methods for randomizing

  • Dr. William Grant
• 20 min
  21. Permutation tests

  • Dr. YanYan Zhou
• 59 min
  22. Handling multiplicity due to multiple primary or composite endpoints in clinical trials

  • Dr. Abdul Sankoh
• 32 min
  23. Multiple analyses in clinical trials

  • Prof. Lemuel Moye
• 26 min
  24. Handling of missing data in clinical trials

  • Dr. Linda Yau
• 35 min
  25. A note on the application of post-randomization adjustment

  • Dr. Xun Chen
• 24 min
  26. N-of-1 randomized clinical trials

  • Prof. Patrick Onghena

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Background
3. Selection bias
4. Randomisation (1)
5. Quasi-alternation
6. True alternation
7. Alternation and selection
8. Randomisation (2)
9. Subversion
10. Foreknowledge of allocation
11. Subversion - evidence
12. Quantitative evidence
13. Poor concealment
14. Comparison of concealment
15. Allocation concealment and sequence generation
16. Concealment
17. More evidence
18. Case study (1)
19. Case study (2)
20. Mean ages of groups
21. More examples
22. Recent blocked trial
23. What is wrong here?
24. Problem?
25. Concealment: recommendations
26. Simple or restricted randomisation?
27. Restricted allocation
28. Blocking
29. What is current practice?
30. Restricted allocation and subversion
31. Possible subversion
32. Wither restricted allocation?
33. Testing for subversion
34. Prediction and cluster randomised controlled trials
35. Cluster trials
36. Consent bias
37. Hip protector trial
38. Review of cluster trials
39. Review results
40. Misleading trial
41. Baseline characteristics
42. Selection bias in recruitment
43. What happened?
44. UK BEAM trial
45. UK BEAM selection bias
46. UK BEAM participant recruitment
47. UK BEAM
48. Avoiding selection bias in cluster trials
49. Selection bias in meta-analysis
50. Selection bias in trials: summary

Topics Covered

• Introduction to selection bias
• Allocation methods
• Evidence for subversion bias
• Restricted or simple randomization
• Problems with cluster randomization
• Evidence for selection bias in cluster trials

Links

Series:

• Design and Analysis of Randomized Clinical Trials

Categories:

• Methods
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. David Torgerson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.