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My name is Roxana Carare.
I'm a clinically
qualified professor
of clinical neuroanatomy.
I'm based in the
University of Southampton
in the United Kingdom.
I have a visiting position also
as a professor in a
Romanian University
and I am chair of
the vascular professional
interests area
of the International
Alzheimer's Association.
I'm going to be talking
to you today about
cerebral amyloid angiopathy
and Alzheimer's disease.
0:41
Alzheimer's disease is the
commonest form of dementia.
What is dementia?
Dementia is an
umbrella term that
encompasses a series of
conditions where there
is loss of recent
memory there could
be loss of intellectual
function from the beginning
and certainly during
the course of
dementia there are personality
changes, but again they
could be from the outset or they
could start developing
later in the course of
the disease and there is
always an effect on emotions,
and it's called
emotional blunting.
So, patients may not
be as responsive to
the normal stimuli that
would generate the
normal emotions.
1:38
Alzheimer's disease is
the communist form of
dementia followed closely by
vascular dementia and then
by dementia with Lewy bodies
and other types of
dementia, such as
fronto-temporal dementia.
It's really important to
distinguish between these
types of dementia, but
also it's very important to
appreciate that when a
patient dies with dementia,
even though they
have been clinically
diagnosed with one type
of dementia or another
quite often the
co-existing pathologies
are found in the brain.
Most frequently, patients
diagnosed as Alzheimer's
disease have an element of
vascular dementia
and patients with
vascular dementia
have an element of
Alzheimer's disease
pathology in their brains.
The reasons for this will become
clearer as I progress
through the presentation.
