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Neuropathology and underlying mechanisms of cerebral amyloid angiopathy

Published on July 31, 2023   13 min

Other Talks in the Series: Cerebral Amyloid Angiopathy (CAA)

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0:00
My name is Susanne van Veluw. I'm an assistant professor of neurology at Mass General Hospital in Boston. In this lecture I will give a basic introduction on the neuropathology of cerebral amyloid and geography and some of the vascular pathology that is associated with these lesions.
0:18
Cerebral amyloid anglopathy, or CAW, is one of the main causes of hemorrhagic stroke and dementia in older individuals and the common cerebral small vessel disease. Neuropathy logically, CAA is characterized by the accumulation of amyloid beta in the walls of cortical and pile surface vessels, which is what you can see on this slide here. This is a thin cut section from a brain of a patient with a clinical diagnosis of CAA taken from the posterior or occipital part of the brain. The brown deposits indicate amyloid-beta that is deposited in the walls of these cortical and leptin meningeal vessels.
0:52
Severe vascular amyloid-beta deposition gives rise to multiple microvascular injuries in the brain, which are here summarized in this slide. On the left-hand side you see the hallmark and characteristic hemorrhagic manifestations of CAA, including cerebral microbleeds, intracerebral hemorrhage and cortical superficial cirrhosis, which is considered a chronic manifestations of convexity. Subarachnoid hemorrhage. On the right-hand side are non hemorrhagic or ischemic tissue injuries that you see earlier in the disease process of CAA, including white matter hyperintensities, cortical microinfarcts, and enlarged perivascular spaces. What I would like to do in this introductory lecture is go over some of those vascular pathologies and share what those look like from a neuropathic logical standard and what the associated vessel pathologies are.

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Neuropathology and underlying mechanisms of cerebral amyloid angiopathy

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