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Cerebral amyloid angiopathy (CAA): a clinical disorder

Published on May 31, 2023   22 min

Other Talks in the Series: Cerebral Amyloid Angiopathy (CAA)

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0:00
Hello, my name is Jean-Claude Barron. I'm a Neurologist with special interest in stroke medicine, and as well as neuroscientist and i'm coordinating this series of talks on Cerebral Amyloid Angiopathy, CAA and this is an introductory talk where I will just briefly go over the main aspects of CAA, and everything I will say, will be developed and expanded within each of the 16 specific talks of this series. What is CAA?
0:42
CAA is defined pathologically by an abnormal deposition of beta amyloid many A-Beta-40 in the media of the small and medium size cortical and leptomeningeal arteries. This is very important to understand that CAA is a disease of the surface of the brain, the meninges, and the surface of the cortex mainly. Diagnosis is made pathologically because the amyloid binds Congo red as shown on the bottom left, and is fluorescent with Thioflevin S. However, to make a specific diagnosis of CAA, it is highly recommended to do immunohistochemistry using a-Beta antibodies as shown on the bottom right.

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Cerebral amyloid angiopathy (CAA): a clinical disorder

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