• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  1. Segregation analysis

  • Prof. Chris Cannings
  • Dr. Dawn Teare
• 35 min
  2. Choosing the right study design in genetic epidemiology

  • Prof. Duncan Thomas
• 27 min
  3. Genome-wide scans

  • Prof. Michael Province
• 40 min
  4. The study of candidate genes in drug trials - sample size considerations

  • Prof. Robert Elston
• 48 min
  5. Graphical modelling of linkage disequilibrium

  • Prof. Alun Thomas
• 50 min
  6. Bayesian approaches for modelling complex metabolic pathways

  • Prof. Duncan Thomas
• 53 min
  7. Current methods for the analysis of genetic case-control data: a review

  • Prof. Duncan Thomas
• 44 min
  8. Detecting and correcting for population structure in genetic case-control studies

  • Dr. Jonathan Pritchard
• 57 min
  9. Statistical characterization of genetic association

  • Prof. Bruce Weir
• 34 min
  10. Haplotype-based mapping and pharmacogenetics

  • Prof. David Goldstein
• 50 min
  11. Genetic linkage analysis

  • Prof. Christopher Amos
• 30 min
  12. Use of DNA pooling in large-scale association studies

  • Prof. Pak Sham
• 29 min
  13. Searching for genetic association using (haplotype) tagging SNPs

  • Prof. David Clayton
• 27 min
  14. Heterogeneity: problems and solutions

  • Prof. Michael Province
• 37 min
  15. Introduction to population genetics 1: single locus

  • Prof. David Balding
  • Dr. Andrew Morris
• 57 min
  16. Haplotype phase inference

  • Prof. Peter Donnelly
• 38 min
  17. Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning

  • Prof. Newton Morton
  • Dr. Andrew Collins
• 58 min
  18. Introductory genetics for statisticians

  • Prof. Robert Elston
• 30 min
  19. Nature, nurture, neither?

  • Prof. Steve Jones
• 35 min
  20. Introduction to population genetics 2: linkage disequilibrium

  • Prof. David Balding
  • Dr. Andrew Morris
• 34 min
  21. Fine-scale mapping

  • Prof. David Balding
  • Dr. Andrew Morris

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genetic association
3. Genotype notation
4. Allele notation
5. One-locus association
6. Inbreeding coefficient
7. Multiple alleles
8. Hardy-Weinberg testing
9. Power of HW test
10. Two-locus association
11. Linkage disequilibrium testing
12. HW, LD statistics comparison
13. Variance of HW, LD statistics
14. Estimating gamete frequencies
15. EM algorithm
16. Composite disequilibrium
17. Composite LD estimate
18. General disease model
19. Disease associations
20. Detecting association with HWD
21. Case-control comparison
22. Case-control test
23. Contingency-table tests
24. Populations not in HWE
25. Haplotype associations
26. Haplotype association parameter
27. Four-locus association
28. Four-locus LD
29. Three-locus LD test
30. Three-locus test partition
31. Two-locus normal-based test
32. Three-locus normal-based test
33. Two-locus LD bounds
34. Two-locus bounds example
35. Three-locus bounds
36. Four-locus bounds
37. References
38. Acknowledgements

Topics Covered

• Alternative methods of estimating and testing hypotheses
• Causes and description of departures from independence of alleles at one, two or three loci
• Effects of multiple alleles
• Comparison of allelic and genotypic association tests in the case-control setting
• Trend tests

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Bruce Weir has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.