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Printable Handouts
Navigable Slide Index
- Introduction
- Biomarker selection
- Background
- General considerations on biomarkers
- Use of biomarkers in translational clinical R&D
- General implications of molecular processes
- Molecular processes in human
- Molecular processes representation
- Clinical phenotypes and disease terms
- Disease terms and molecular processes
- 1:1 relation
- Phenotypes, molecular processes, biomarkers
- Phenotypes, molecular processes, biomarkers (2)
- Phenotypes, molecular processes, biomarkers (3)
- 1:n relation
- Example: diabetic nephropathy
- Biomarkers for onset and progression of DN
- Disease terms and underlying process view
- Disease term process landscape (1)
- Disease term process landscape (2)
- Assumption
- Options in biomarker discovery, applications (1)
- Options in biomarker discovery, applications (2)
- Implications and use
- Biomarker panel discovery
- Basis: annotated relations networks
- Step 1: retrieve disease phenotype data
- Step 2: populate an interaction network
- Step 3: extract disease term-specific subgraph
- Step 4: subgraph segmentation
- Step 5: select for each process a marker
- Result
- Example: application of the steps
- DN data retrieval and consolidation
- DN subgraph construction
- DN subgraph and molecular process model
- Biomarker candidate panel selection
- Recall: scope and purpose
- Outlook: from marker panels to stratification
- Summary and key issues
- Acknowledgements
- Thank you!
Topics Covered
- Biomarkers
- Molecular processes
- Disease terms
- Multimarker panels
- Cross-Omics
- Interaction networks
- Molecular disease models
- Biomarker selection
- Chronic disease
- Patient stratification
Talk Citation
Mayer, B. (2013, November 5). A concept for multi-marker approaches in clinical proteomics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/RCUT3673.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Bernd Mayer, Grant/Research Support (Principal Investigator): European Union FP& project SysKid (Systems Biology towards novel chronic kidney disease diagnosis and treatment) ; Stock Shareholder (Self-managed): emergentec biodevelopment GmbH, Gersthofer Str. 29-31, 1180 Vienna, Austria.