Trauma-informed care (TIC)
61 min
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- Clinical Physiology of the Kidneys
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27 min
1. Molecular basis of genetic renal diseases 1- Dr. Paul Jennings
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25 min
2. Molecular basis of genetic renal diseases 2- Dr. Paul Jennings
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36 min
3. Assessment of renal function- Dr. Jochen Raimann
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30 min
4. Isolated microhematuria and proteinuria in adults- Dr. Eva Seiringer
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19 min
5. Intradialytic oxygen saturation- Dr. Lili Chan
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28 min
6. Pervasive sensing in chronic kidney disease- Ms. Maggie Han
- Ms. Schantel Williams
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52 min
7. The genetic basis of kidney cancer- Dr. W. Marston Linehan
- Glomerular Disorders
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38 min
8. Focal segmental glomerulosclerosis- Prof. Moin Saleem
- Tubular Interstitial Disorders
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23 min
9. What’s new for IgA nephropathy part 1: epidemiology and pathogenesis- Prof. Maurizio Salvadori
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23 min
10. What’s new for IgA nephropathy part 2: clinical presentation, diagnosis, prognosis, treatment- Prof. Maurizio Salvadori
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31 min
11. Renal complications of sickle cell disease- Dr. Claire Sharpe
- Acute Kidney Injury
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30 min
- Chronic Kidney Disease
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24 min
13. Pathophysiology of acute renal failure- Dr. Viviane Calice-Silva
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29 min
14. Anaemia in chronic kidney disease- Prof. Iain Macdougall
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41 min
15. Kidney disease and pregnancy: a new era?- Dr. Kate Bramham
- Renal Cell Carcinoma
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47 min
16. The genetics and genomics of familial renal carcinoma- Prof. Eamonn Maher
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58 min
17. Immune checkpoint blockade in renal cell carcinoma- Prof. David McDermott
- Pharmacology and the Kidney
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30 min
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62 min
19. Toxicology of the kidney- Prof. Lawrence Lash
- Proteomics and the Kidney
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40 min
20. Proteomics in diabetic kidney disease- Prof. Peter Rossing
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53 min
21. Urinary proteomics in kidney and cardiovascular disease- Prof. Harald Mischak
- Pediatric Nephrology
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45 min
22. Continuous renal replacement therapy (CRRT) in children- Prof. Timothy E. Bunchman
- Archived Lectures *These may not cover the latest advances in the field
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38 min
23. Proteomics in kidney disease: clinical considerations- Prof. Peter Rossing
Printable Handouts
Navigable Slide Index
- Introduction
- Agenda
- Proteomics: definition
- Discovery of new markers
- Proteomic utility in DN (Diabetic Nephropathy)
- Albuminuria and mortality in DM individuals
- RENAAL trial
- Early intervention?
- Natural history of diabetic nephropathy
- U-albumin
- Hypothesis driven search for new biomarkers
- Growth differentiation factor 15
- Multimarker proteomic techniques
- Plasma proteomic analysis
- Plasma proteome analysis of T1D patients
- Network analysis on the case control ratio
- Kininogen and kininogen fragments as markers
- Erk 1/2 phosphorylation in tubular cell lines
- CDK prediction post liver transplantation (1)
- CDK prediction post liver transplantation (2)
- Urine proteomic profiling
- CE-MS proteomic technique
- Proteomics technology platform
- Individual analyses to compiled patterns
- Individual analyses to compiled patterns: Example
- Proteomic CKD biomarker discovery
- CKD-biomarkers: collagen
- CKD-biomarkers: apoptosis related proteins
- Pathophysiological suggestions
- Proteomic profile of T1DM with or without DN
- Candesartan in T2DM and DN
- Prediction analysis
- Urinary protein profiles of ADPKD patients
- Urinary proteomics in Fabry and controls
- Profiles of ERT treated female Fabry patients
- Marker implementation
- Systems biology in CKD
- Conclusions
- Perspectives
- Priority EU project
- Priority EU project in details
- Thank you for listening
- Acknowledgements
Topics Covered
- Proteomics for clinical use
- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search
- Open or unbiased multimarker approaches including plasma and urine proteomics
- Examples from different renal diseases
- Data from cross sectional and longitudinal studies
- Proteomics may provide insight into disease pathology
- Proteomics may provide risk stratification for clinical trials
- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern
Links
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Talk Citation
Rossing, P. (2013, November 5). Proteomics in kidney disease: clinical considerations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 24, 2024, from https://doi.org/10.69645/XPCZ7201.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Rossing has received the following: Consultancy and/or speaking fees (to his institution) from Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, MSD, Novo Nordisk and Sanofi Aventis, Research grants from AstraZeneca Bayer and Novo Nordisk.
