• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  1. Segregation analysis

  • Prof. Chris Cannings
  • Dr. Dawn Teare
• 35 min
  2. Choosing the right study design in genetic epidemiology

  • Prof. Duncan Thomas
• 27 min
  3. Genome-wide scans

  • Prof. Michael Province
• 40 min
  4. The study of candidate genes in drug trials - sample size considerations

  • Prof. Robert Elston
• 48 min
  5. Graphical modelling of linkage disequilibrium

  • Prof. Alun Thomas
• 50 min
  6. Bayesian approaches for modelling complex metabolic pathways

  • Prof. Duncan Thomas
• 53 min
  7. Current methods for the analysis of genetic case-control data: a review

  • Prof. Duncan Thomas
• 44 min
  8. Detecting and correcting for population structure in genetic case-control studies

  • Dr. Jonathan Pritchard
• 57 min
  9. Statistical characterization of genetic association

  • Prof. Bruce Weir
• 34 min
  10. Haplotype-based mapping and pharmacogenetics

  • Prof. David Goldstein
• 50 min
  11. Genetic linkage analysis

  • Prof. Christopher Amos
• 30 min
  12. Use of DNA pooling in large-scale association studies

  • Prof. Pak Sham
• 29 min
  13. Searching for genetic association using (haplotype) tagging SNPs

  • Prof. David Clayton
• 27 min
  14. Heterogeneity: problems and solutions

  • Prof. Michael Province
• 37 min
  15. Introduction to population genetics 1: single locus

  • Prof. David Balding
  • Dr. Andrew Morris
• 57 min
  16. Haplotype phase inference

  • Prof. Peter Donnelly
• 38 min
  17. Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning

  • Prof. Newton Morton
  • Dr. Andrew Collins
• 58 min
  18. Introductory genetics for statisticians

  • Prof. Robert Elston
• 30 min
  19. Nature, nurture, neither?

  • Prof. Steve Jones
• 35 min
  20. Introduction to population genetics 2: linkage disequilibrium

  • Prof. David Balding
  • Dr. Andrew Morris
• 34 min
  21. Fine-scale mapping

  • Prof. David Balding
  • Dr. Andrew Morris

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline of talk
3. Definitions
4. Concepts of meiosis
5. Meiosis and recombination
6. Phasing
7. Linkage analysis, phase known
8. Linkage analysis of phase known family
9. LOD Score
10. Estimation and testing
11. Phase unknown example
12. Classic paradigm for isolating genetic effects
13. Selection of families for segregation
14. Segregation analysis versus linkage analysis
15. Penetrance and linkage
16. Elston-Stewart algorithm (1)
17. Elston-Stewart algorithm (2)
18. Elston-Stewart algorithm (3)
19. Elston-Stewart algorithm for linkage
20. Implementing the Elston-Stewart algorithm
21. Programs using the Elston-Stewart algorithm
22. The Lander-Green algorithm
23. Implementing the L-G algorithm (1)
24. Implementing the L-G algorithm (2)
25. How to model larger pedigrees?
26. Modeling larger pedigrees
27. Effect of locus heterogeneity
28. Locus heterogeneity
29. Multipoint linkage analysis: no locus heterogeneity
30. Multipoint linkage analysis: heterogeneity
31. Biases in data from an incorrect genetic model
32. How can we detect linkage?
33. Linkage analysis for uncertain models
34. Gene I.B.D.
35. Model-free analysis for diseases
36. Analyzing complex pedigrees
37. Haseman-Elston test for genetic linkage (1)
38. Haseman-Elston test for genetic linkage (2)
39. Variance-components: tests for linkage
40. Variance components analysis
41. Summary
42. References

Topics Covered

• Likelihood formulations for genetic analysis of family data
• The statistical framework for segregation and linkage analysis
• Types of sampling approaches useful for linkage analysis
• Modelling of linked genetic markers
• The impact of linkage disequilibrium on ability to detect linkage
• Modelling using less fully parametric approaches
• The affected sib pair and variance components approaches

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Christopher Amos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.