• Basic Concepts
• 19 min
  1. Molecular structure of the human genome

  • Prof. Jonathan Wolfe
• 31 min
  2. Introduction to mutation and disease

  • Prof. Jonathan Wolfe
• 26 min
  3. Introduction to genetic diseases

  • Prof. Jonathan Wolfe
• 26 min
  4. Historical introduction to human diversity I

  • Prof. Dallas Swallow
• 28 min
  5. Historical introduction to human diversity II

  • Prof. Dallas Swallow
• 23 min
  6. Introduction to cytogenetics 1

  • Dr. Sioban SenGupta
• 15 min
  7. Introduction to cytogenetics 2

  • Dr. Sioban SenGupta
• 16 min
  8. Introduction to cytogenetics 3

  • Dr. Sioban SenGupta
• 42 min
  9. The Y-chromosome

  • Prof. Mark Jobling
• 42 min
  10. Mitochondrial DNA, molecular genetics and human mitochondrial diseases

  • Prof. Immo Scheffler
• 66 min
  11. Mechanisms of DNA repair by recombination

  • Prof. James Haber
• 26 min
  12. Techniques utilized in molecular genetics

  • Dr. Cecil Lewis
• 36 min
  13. Genome mapping

  • Dr. Simon Gregory
• 35 min
  14. Copy number variation

  • Dr. Ömer Gökçümen
• Genetics and Disease
• 45 min
  15. Genetic association studies

  • Prof. David Balding
• 42 min
  16. Quantitative genetics and multifactorial inheritance

  • Dr. Lara Bauman
• Human Evolutionary Genetics
• 34 min
  17. Population genetics

  • Dr. Murray P. Cox
• 59 min
  18. Inference on human history through DNA

  • Prof. Guido Barbujani
• 37 min
  19. Human adaptation

  • Prof. Rasmus Nielsen
• Specialized Topics
• 44 min
  20. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 44 min
  21. Pharmacogenetics

  • Prof. Ann Daly
• 33 min
  22. Genetics in forensics

  • Dr. Angel Carracedo
• 29 min
  23. The development and evolution of human gene therapy

  • Prof. Theodore Friedmann
• 33 min
  24. Next generation sequencing technologies

  • Dr. Krishna Veeramah

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Genetics influence traits
3. What is a quantitative trait?
4. Quantitative and multifactorial inheritance
5. Some history
6. Some more history
7. Basic biometric model (1)
8. Basic biometric model (2)
9. Basic biometric model (3)
10. Identity states
11. Identity coefficients
12. Kinship coefficients
13. Covariances for relatives (1)
14. Covariances for relatives (2)
15. Polygenic model (1)
16. Polygenic model (2)
17. Add environment
18. Modeling environment/error
19. Household effects models
20. Variance component models
21. Statistical process
22. A gene x environment model
23. Why? how?
24. G x E model, mean
25. G x E model, variance
26. The San Antonio family heart study
27. The data
28. The questions
29. The results, mean
30. Gene ontology analysis
31. The results, heritability
32. GO BP results poly G x S
33. GO-BP graph for sig poly G x S
34. QTL mapping uses genotype data
35. Genotyping
36. QTL mapping
37. Multivariate model
38. SAFADS example
39. Insulin Resistance Syndrome (IRS)
40. Four trait heritability analysis
41. QTL mapping process (1)
42. QTL mapping process (2)
43. FSI, BMI, leptin and DBP (1)
44. FSI, BMI, leptin and DBP (2)
45. Thanks
46. References

Topics Covered

• Basic Biometric Model: single locus model, identity states and coefficients, Covariances for relatives, polygenic model
• Modeling environment/error
• Gene by environment interaction model and example
• QTL mapping model
• Multivariate model and example

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on May 22, 2012

Financial Disclosures

• Dr. Lara Bauman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.