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Welcome to this lecture entitled Chemical Synthesis.
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Sources of chemicals. There is a need for an accessible source of chemicals and reagents in order to achieve the required synthesis. Pharmaceutical companies often store large compound libraries that contain natural as well as synthetic compounds. These then are readily available for drug discovery by direct assessment or for the use as building blocks for further synthesis or modification.
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Synthesis of chemical entities. The route of synthesis is carefully planned accounting for ease, purity and overall yield of the required product. Combinatorial approaches have been used to produce large numbers of related chemicals for utilization in drug discovery programs.
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Rational drug design. Virtual modeling in silico can provide the basis for the drug design prior to the commitment to chemical synthesis. There is the concept of a pharmacophore. This is the molecular representations needed for a suitable ligand and target interaction. An approach to generating a useful chemical entity can be via a rational approach to drug design, in which the 3D space of the target molecule is considered. Similarly, the 3D space of the binding ligand is considered in order to design an appropriate and often high-affinity binding agent taking into account the stereochemistry.

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