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My name is Dr. Wayne Carter.
Welcome to this lecture
entitled Drug Pharmacokinetics.
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Pharmacokinetics.
Drug pharmacokinetics (PK)
relates to the kinetics,
that is the movement of a drug
into and out of the body.
In other words, what the
body does to the drug.
Drug pharmacokinetics are often
conveniently divided
into four parts,
abbreviated as ADME,
which stands for absorption,
distribution, metabolism,
and excretion.
Root of drug administration into
the body and its takeup
is the drug absorption.
The passage of the drug
through the body and
its localization is
the drug distribution.
If and how the drug gets
broken down and modified,
that is biotransformed,
is the drug metabolism.
How and the route by which
the body expels the drug
and/or its metabolites
is the excretion.
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Absorption. The pharmacokinetics
and drug processing
will be influenced by
the route of exposure.
The administration
of a chemical entity
(drug) is most commonly
by an oral route,
and this is for the
majority of drugs.
But also other
alternative routes,
such as skin (subcutaneous) or
intravenous (IV) routes,
are often undertaken.
Oral routes will need to pass
into the stomach and then
normally pass into
the intestines
before absorption
into the bloodstream.
And they therefore may undergo
metabolism typically
in the liver.
Whereas subcutaneous roots can
be particularly
useful for local,
say skin topical
application and like
IV roots can often rapidly
enter the bloodstream
without further metabolism.
