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Parkinson's Disease

Launched June 2014 Updated December 2024 18 lectures
Summary

In recent years, considerable advances have been made in our understanding of Parkinson's disease. In particular, information on genetic contributions to disease etiology has expanded and an increased awareness of the incidence and importance of non-motor features. Theories relating to pathogenesis and pathophysiology have been refined and new treatment modalities... read moreimplemented.

This series will cover both preclinical and clinical science, providing a resource for all Parkinson’s disease researchers.

The preclinical section of the series covers the anatomical and biochemical changes associated with Parkinson’s disease as well as the genetic factors which can influence it.

The clinical section of the series covers methods for assessing the progression of Parkinson’s disease (including non-motor symptoms), treatment of patients and likely developments in the future.

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Basic (Preclinical) Science (9 Lectures)  

Anatomical organization of the basal ganglia
46 min
  • Prof. Andre Parent
  • Université Laval Quebec City, Quebec, Canada
Synaptic plasticity in striatal function
37 min
  • Prof. Paolo Calabresi
  • University of Perugia, Italy
Oscillatory neuronal activity patterns in Parkinson’s disease
46 min
  • Prof. Thomas Wichmann
  • Emory University, USA
The thalamic regulation of striatal function in normal and Parkinsonian states
38 min
  • Prof. Yoland Smith
  • Emory University, USA
Mechanisms of L-DOPA-induced dyskinesia in Parkinson's disease
44 min
  • Prof. Angela Cenci
  • University of Lund, Sweden
Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson’s disease
35 min
  • Prof. Anthony Schapira
  • Department of Clinical Neurosciences, University College London, UK
Purines in Parkinson's: from epidemiology of caffeine and urate to therapeutics
62 min
  • Dr. Michael Schwarzschild
  • Harvard University, USA
Deep brain stimulation: a mysterious success or a clue to help localize the causes of Parkinsonism?
28 min
  • Prof. Gordon Arbuthnott
  • Okinawa Institute of Science & Technology, Japan
Prion-like propagation of Parkinson's disease
61 min
  • Prof. Patrik Brundin
  • Van Andel Research Institute, USA and Lund University, Sweden

Clinical Science (9 Lectures)  

Clinical presentation of Parkinson’s disease 1
31 min
  • Prof. Stewart A. Factor
  • Emory University School of Medicine, USA
Clinical presentation of Parkinson’s disease 2
55 min
  • Prof. Stewart A. Factor
  • Emory University School of Medicine, USA
Promising medical therapies for Parkinson’s disease
41 min
  • Prof. Robert A. Hauser
  • University of South Florida, USA
Deep brain stimulation for Parkinson’s disease
51 min
  • Prof. Michael S. Okun
  • University of Florida, USA
When is it useful to genotype Parkinson's disease patients?
20 min
  • Prof. Zbigniew Wszolek
  • Mayo Clinic Florida, Jacksonville, USA
Leucine-rich repeat kinase 2 (LRRK2)
26 min
  • Prof. Mark Cookson
  • NIH, USA
Autonomic dysfunction in Parkinson’s disease
67 min
  • Prof. Ronald Pfeiffer
  • University of Tennessee, USA
Cardiovascular involvement in Parkinson’s disease
57 min
  • Dr. David S. Goldstein
  • National Institutes of Health (NIH), USA
Non-motor symptoms: Impulse control disorders and dopamine dysfunction in Parkinson's disease
28 min
  • Prof. Antonio Strafella
  • University of Toronto, Canada