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My name is Susanne van Veluw.
I'm an assistant
professor of neurology at
Mass General Hospital in Boston.
In this lecture I will
give a basic introduction
on the neuropathology
of cerebral amyloid and
geography and some of
the vascular pathology that
is associated with
these lesions.
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Cerebral amyloid
anglopathy, or CAW,
is one of the main causes of
hemorrhagic stroke
and dementia in
older individuals and
the common cerebral
small vessel disease.
Neuropathy logically, CAA is
characterized by
the accumulation of
amyloid beta in the walls of
cortical and pile
surface vessels,
which is what you can
see on this slide here.
This is a thin cut section
from a brain of a patient with
a clinical diagnosis
of CAA taken
from the posterior or
occipital part of the brain.
The brown deposits indicate
amyloid-beta that is
deposited in the walls of
these cortical and leptin
meningeal vessels.
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Severe vascular amyloid-beta
deposition gives rise
to multiple microvascular
injuries in the brain,
which are here summarized
in this slide.
On the left-hand side
you see the hallmark and
characteristic hemorrhagic
manifestations of CAA,
including cerebral microbleeds,
intracerebral hemorrhage and
cortical superficial cirrhosis,
which is considered a chronic
manifestations of convexity.
Subarachnoid hemorrhage.
On the right-hand side are
non hemorrhagic or
ischemic tissue injuries
that you see earlier in the
disease process of CAA,
including white matter
hyperintensities,
cortical microinfarcts,
and enlarged
perivascular spaces.
What I would like to do in
this introductory lecture
is go over some of those
vascular pathologies and
share what those look like from
a neuropathic logical standard
and what the associated
vessel pathologies are.
