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Immune Checkpoint Inhibitors

This learning journey is designed to introduce immune checkpoint inhibition in cancer immunotherapy, and how it works. Two specific types of inhibitors: CTLA-4 inhibitors and PD-1/PD-L1 inhibitors are discussed, and the role of checkpoint blockade in specific solid tumours is also explored.

Table of Contents

  1. Tumour Immunity and Checkpoint Inhibition
  2. Opportunities for Immunotherapy in Cancer
  3. Immunotherapy to Immune Checkpoint Inhibition
  4. Checkpoint Blockade
  5. CTLA-4 Inhibitors in Melanoma
  6. CTLA-4 Inhibitors in Hepatocellular Carcinoma
  7. PD-1 and PD-L1 Inhibitors Monotherapy in Breast Cancer
  8. PD-1 and PD-L1 Inhibitors in Lung Cancer
  9. PD-1 and PD-L1 Inhibitors in Melanoma
  10. Checkpoint Inhibition in Haematology

1. Tumour Immunity and Checkpoint Inhibition

By Dr. Elizabeth Buchbinder – Harvard Medical School, USA

An excerpt from Immune checkpoint blockade in melanoma

  • Play Tumour Immunity and Checkpoint Inhibition

2. Opportunities for Immunotherapy in Cancer

By Prof. Tim Elliott – University of Oxford, UK

An excerpt from Cancer immunotherapy

  • Play Opportunities for Immunotherapy in Cancer

3. Immunotherapy to Immune Checkpoint Inhibition

By Dr. Md. David A. Reardon – Center for Neuro-Oncology Dana-Farber Cancer Institute, USA

An excerpt from Immune checkpoint blockade in CNS tumors

  • Play Immunotherapy to Immune Checkpoint Inhibition

4. Checkpoint Blockade

By Prof. Tim Elliott – University of Oxford, UK

An excerpt from Cancer immunotherapy

  • Play Checkpoint Blockade

5. CTLA-4 Inhibitors in Melanoma

By Dr. Elizabeth Buchbinder – Harvard Medical School, USA

An excerpt from Immune checkpoint blockade in melanoma

  • Play CTLA-4 Inhibitors in Melanoma

6. CTLA-4 Inhibitors in Hepatocellular Carcinoma

By Prof. Tim Greten – Senior Investigator, Bethesda, USA

An excerpt from Immunotherapy of hepatocellular carcinoma

  • Play CTLA-4 Inhibitors in Hepatocellular Carcinoma

7. PD-1 and PD-L1 Inhibitors Monotherapy in Breast Cancer

By Dr. Sara M. Tolaney – Dana-Farber Cancer Institute and Harvard Medical School, USA

An excerpt from Immunotherapy: insights from advanced disease

  • Play PD-1 and PD-L1 Inhibitors Monotherapy in Breast Cancer

8. PD-1 and PD-L1 Inhibitors in Lung Cancer

By Dr. Mark M. Awad – Dana-Farber Cancer Institute, USA

An excerpt from Immunotherapy in lung cancer

  • Play PD-1 and PD-L1 Inhibitors in Lung Cancer

9. PD-1 and PD-L1 Inhibitors in Melanoma

By Dr. Elizabeth Buchbinder – Harvard Medical School, USA

An excerpt from Immune checkpoint blockade in melanoma

  • Play PD-1 and PD-L1 Inhibitors in Melanoma

10. Checkpoint Inhibition in Haematology

By Prof. Mark Cragg – University of Southampton, UK

An excerpt from Monoclonal antibodies in haemato-oncology

  • Play Checkpoint Inhibition in Haematology