The migraine pathway: diagnosis, chronification, and treatment

This learning journey explores the complex nature of migraine, starting from the fundamental mechanisms of pain and its global impact, to the clinical challenges of diagnosis and chronicity. It delves into the classification of headaches, highlights key diagnostic criteria, and examines risk factors contributing to migraine chronification. Finally, it reviews the neurobiology behind migraine and current therapeutic targets, providing a comprehensive understanding of migraine management.


1. Migraine: Why it hurts and how we react

By Prof. Robert P. Cowan – Stanford University School of Medicine, USA

An excerpt from Headache and migraine: theory, practice, and challenges


2. Migraine by the numbers: A global health perspective

By Dr. Oyindamola I. Ogunlaja – Stanford University, USA

An excerpt from Epidemiology and global burden of headache and migraine


3. The key to headache diagnosis: Know what you're treating

By Dr. Sara Sacco – Carolinas Headache Clinic, USA

An excerpt from Classification of headache disorders


4. Migraine diagnosis: What you need to know

By Dr. Sara Sacco – Carolinas Headache Clinic, USA

An excerpt from Classification of headache disorders


5. Secondary headaches: What to watch for

By Dr. Sara Sacco – Carolinas Headache Clinic, USA

An excerpt from Classification of headache disorders


6. Chronic migraine: Where definitions diverge

By Dr. Stewart J. Tepper – The New England Institute for Neurology and Headache, USA

An excerpt from Chronic migraine: history, imaging and patient characteristics, and controversies


7. Unmasking chronic migraine: The real clinical picture

By Dr. Stewart J. Tepper – The New England Institute for Neurology and Headache, USA

An excerpt from Chronic migraine: history, imaging and patient characteristics, and controversies


8. Why some migraines become chronic

By Prof. Robert P. Cowan – Stanford University School of Medicine, USA

An excerpt from Phenotyping the migraine patient


9. Migraine mechanisms and medication targets

By Prof. Alan M. Rapoport – University of California in Los Angeles, USA

An excerpt from Update on treatment of migraine