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Genevieve Almouzni completed a PhD with Dr. M. Mechali at the Jacques Monod Institute (Paris) and postdoctoral training at the National Institutes of Health (Bethesda) with Dr. A. Wolffe before joining the Curie Institute and establishing her group. Dr. Almouzni is interested in the interrelationships between nuclear organisation and the... read moreDNA metabolism, including DNA replication repair and transcription. The unifying theme underlying her work is the wish to understand the principles governing chromatin dynamics, nuclear organization and functions. A key issue is how these events are coordinated in order to ensure the maintenance of a cellular identity throughout cell divisions. A special emphasis is given to developmental context and genotoxic stress to appreciate the importance of factors involved in chromatin dynamics (CAF-1, HIRA, ASF1, histone variants). Her interest in the 3D organization of the cell nucleus is aimed at understanding how specific domains like pericentric heterochromatin can be stably maintained.