Prof. Thomas Malek University of Miami, USA

1 Talk

Dr. Thomas Malek is Professor and Chair in the Department of Microbiology and Immunology at the University of Miami Miller School of Medicine. He has a long-standing interest in IL-2R signaling and regulatory T cell development and function. His group first showed the critical reliance of regulatory T cells for... read moreIL-2 and later established that low IL-2R signaling effectively supports regulatory but not effector T cells, providing a scientific underpinning for low-dose IL-2 to boost regulatory T cells in the context of autoimmunity. More recently his group developed a novel IL-2-based biologic, IL-2/CD25, which has many favorable properties when compared to IL-2 for use in autoimmunity and cancer. Current research investigates the cellular and molecular mechanisms behind the therapeutic benefit of IL-2/CD25 to facilitate clinical translation.