Prof. Bob Brown Imperial College London, UK

1 Talk

Robert Brown is Professor of Translational Oncology, Head of Division of Cancer and Head of Epigenetics Unit, Department of Surgery & Cancer, Imperial College London and the Section of Medicine at the Institute of Cancer Research, Sutton. He is a Principal Investigator of Cancer Research UK research programme, Drug Resistance... read moreand Epigenetics and co-Principal Investigator in the Ovarian Cancer Action Research Centre and CRUK/NIHR Experimental Cancer Research Centre. Professor Brown's work focuses on epigenetics and drug resistance research, with a particular focus on ovarian cancer. He examines how tumors acquire resistance to chemotherapy and approaches to improving treatment by overcoming drug resistance. He and his team have shown that aberrant DNA methylation and epigenetic silencing of genes in tumors can predict response to chemotherapy and patient survival. As part of his work, Robert is also facilitating development of compounds which can reverse epigenetic silencing and is using molecular biomarker assays to aid the clinical use of these compounds. Recently, he has initiated studies on identifying such targets in ovarian tumor stem cells.