Dr. Kevin J. Downes University of Pennsylvania, USA

Kevin J. Downes, MD is an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia (CHOP) and an Assistant Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Downes is the Program Director of the Clinical Pharmacology Postdoctoral Training Program... read moreat CHOP, which is a combined adult and pediatric clinical pharmacology training program with Thomas Jefferson University. He is the Associate Director of CHOP’s Small Molecules and Metabolite Core Laboratory and serves as the clinical director of the Solid Organ Transplant Infectious Diseases program for the Division of Infectious Diseases at CHOP. Dr. Downes’s research aims to better understand antimicrobial dose optimization and pharmacokinetics/pharmacodynamics (PK/PD) in children. His lab is focused on how antimicrobial dosing and administration impacts outcomes, such as organ function recovery, the development of adverse effects, and antimicrobial resistance. His work emphasizes development and implementation of personalized, target-oriented approaches for dosing of antimicrobials in critically ill and immunocompromised children using population PK modeling and Bayesian dose adaptation, as well as identifying ways to improve therapeutic drug monitoring in children.