Prof. Norbert Perrimon Harvard Medical School, USA

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Biography

Norbert Perrimon is the James Stillman Professor of Developmental Biology in the Department of Genetics at Harvard Medical School, an Investigator of the Howard Hughes Medical Institute, and an Associate member of the Broad Institute. His laboratory has pioneered a number of techniques in Drosophila such as the FLP-FRT Dominant... read moreFemale Sterile technique to generate germline mosaics, the GAL4-UAS method to control gene expression both spatially and temporally, highthroughput genome wide RNAi and CRISPR screens, and proximity labeling methods to identify secreted molecules. These methods have had transformative impacts in signal transduction, development, physiology, neurobiology, and functional genomics. Early in his career, he identified and characterized factors involved in RTK, Wnt, and JAK/STAT signaling, contributing to the elucidation of these canonical pathways. His lab went on to discover intestinal stem cells in the adult fly gut, opening up an entire field of study to identify factors and pathways involved in stem cell homeostasis and regeneration. In more recent years, he has taken a systematic approach to identify factors involved in inter-organ communication, which are leading to a systems wide understanding of how hormonal systems are regulated by the state of various organs in homeostatic and stressed conditions. Perrimon has been on the faculty of Harvard Medical School since 1986. He received the George W. Beadle Medal form the Genetics Society of America in. 2004. He has been elected to the American Academy of Arts and Sciences, American Association for the Advancement of Science, EMBO, and National Academy of Sciences. He has trained more than 110 students and postdoctoral fellows, with most of them currently holding academic positions.