Henry Stewart Talks

The Biomedical & Life Sciences Collection

Online Seminars By Leading World Experts
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Welcome to The Biomedical & Life Sciences Collection

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This collection of specially prepared animated audio visual presentations with synchronized narration is regularly updated and growing with over 1,500 talks.

RECENTLY ADDED TALKS  View All

Play 'Understanding poor Lymphatic function and how to improve it: Revisiting old facts and examining new leads to help wounds heal'

TOPICS COVERED IN THIS TALK

  • Lymphoedema and oedema: key differences
  • Blood-tissue-lymph systems and their interfaces
  • Importance of the lymphatic system
  • Organization of superficial lymph system
  • Functioning of the lymphatic system
  • Consequences of poor lymph flow
  • Deep and superficial systems
  • The adipo-lymphatic connection
  • Fats in the diet: How they affect lymph flow and load
  • Lymphatic drainage from the small intestine
  • Blockage/overload and chylous reflux
  • Factors which determine lymph load and flow
  • Development of lymphoedema
  • Types of lymphoedemas
  • Increased subcutaneous fat reduces lymph transport
  • Build-up of fibrous tissues reduces lymphatic function
  • The problems of fibrosis
  • Proximity issues
  • Other limb swellings which look like lymphoedema which may underlie the wound area: Lipoedemas, Myxoedema and Phlebo-lymphoedema
  • Adipose tissue, fibrosis and lymphoedema
  • What can be done to improve tissue/cell health and improve wound healing?
Play 'The genetic basis of kidney cancer'
The genetic basis of kidney cancer More info
Dr. W. Marston Linehan

TOPICS COVERED IN THIS TALK

  • Renal Carcinoma
  • Stage I , Stage IV kidney cancer
  • Human Renal Epithelial Neoplasms
  • Loss of alleles in renal cell carcinoma
  • Mapping the Minimal 3p Loss Region in Clear Cell Renal Carcinoma
  • Studying Cancer Families to Identify Renal Carcinoma Genes
  • Identification of Kidney Cancer Genes
  • Inherited Forms of Renal Carcinoma
  • Clear Cell Renal Carcinoma: von Hippel Lindau (VHL)
  • VHL Gene
  • VHL Gene Localization Map
  • Germline VHL Mutations
  • Papillary Renal Carcinoma
  • Mouse Studies of VHL gene
  • VHL Gene Function
  • HIFα
  • Downstream effects of VHL mutation
  • Targeting VHL/HIF in Clear Cell RCC
  • TCGA Clear Cell Kidney Cancer
  • Intratumor Heterogeneity
  • Warburg effect in clear cell kidney cancer
  • Non-Clear Cell RCC
  • Locally Advanced Kidney Cancer
  • Hereditary Papillary Renal Carcinoma (HPRC)
  • Inherited Renal Carcinoma
  • Type 1 Papillary Renal Carcinoma
  • Penetrance of MET Mutation H1210R
  • MET Gene: Type 1 Papillary RCC
  • Location of the HPRC Gene
  • HPRC: Activating Mutations in the Tyrosine Kinase Domain of MET
  • Location of MET Mutations in the HPRC Patients
  • Targeting MET RCC Gene Pathway
  • Potential Small Molecule Target: MET Tyrosine Kinase Inhibition
  • Foretinib: Dual VEGFR and MET Inhibitor
  • MiT Kidney Cancer TFE3, TFEB, MITF
  • UOK124, Papillary Kidney Cancer
  • UOK124, UOK120, UOK 146 & TFE3 Kidney Cancer
  • Inherited Renal Carcinoma Birt-Hogg-Dubé (BHD)
  • Birt Hogg Dubé Cutaneous Manifestations
  • Kidney Tumors in BHD
  • BHD Renal Tumor Pathology
  • BHD Lung Cysts
  • Identification of the BHD Gene
  • Cutaneous Fibrofolliculomas
  • BHD Gene: Chromophobe RCC
  • BHD Gene Locus: Chromosome 17
  • BHD Protein Sequence
  • FLCN Mutation Spectrum
  • Therapeutic Approach: What Kind of Gene is FLCN?
  • BHD Gene Analysis in BHD-Associated RCC
  • Somatic mutations in renal tumors from BHD patients
  • UOK 257, BHD -/- RCC cell line Study
  • How Does the FLCN Gene Function?
  • Folliculin-FNIP1/2-AMPK Interactions
  • mTORC1/mTORC2 Activation: FLCN-Deficient Kidney Cancer
  • BHD Deletion Specifically in the Kidney
  • BHDf/d/KSPCre Mouse Kidney Study
  • Hereditary Leiomyomatosis Renal Cell Carcinoma (HLRCC)
  • HLRCC: Cutaneous Manifestations, Uterine Leiomyomas
  • HLRCC: Papillary Kidney Cancer Type 2
  • Orangophilic Nucleoli + Perinucleolar Halos
  • Fumarate Hydratase Gene: HLRCC
  • UOK-262 Study
  • Loss of a Krebs Cycle Enzyme Can Lead to Kidney Cancer
  • Impaired citric acid cycle and “Warburg effect”
  • HLRCC-Renal Cancer: Glucose-Dependent
  • PET Scan
  • HLRCC novel treatment approaches
  • Kidney Cancer: a Metabolic Disease
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FREE TALK OF THE MONTH

Play 'Gene therapy and virotherapy in the treatment of cancer'
Gene therapy and virotherapy in the treatment of cancer More info
Prof. Leonard Seymour

TOPICS COVERED IN THIS TALK

  • Mutations and microenvironment in cancer
  • The challenge of cancer gene therapy
  • Cancer gene therapy strategies: p53 and TNF
  • Virotherapy against tumour cells
  • Virotherapy studies with wild-type vs. genetically-engineered viruses (Adenovirus, Vaccinia & Herpes)
  • Future of cancer virotherapy

POPULAR TALKS

Play 'Manufacturing viral gene therapy vectors: general approaches and challenges'
Manufacturing viral gene therapy vectors: general approaches and challenges More info
Prof. John T. Gray
UG 

TOPICS COVERED IN THIS TALK

  • Manufacturing of Viral Gene Therapy Vectors
  • Different types of vector production systems
  • Concepts for the design of viral vector production cells
  • Specific viral vector production systems for adenovirus, adeno-associated virus, gamma-retrovirus, and lentivirus
  • Downstream processing
  • Regulatory considerations
Play 'The genetics of frontotemporal dementia'
The genetics of frontotemporal dementia More info
Prof. John Hardy

TOPICS COVERED IN THIS TALK

  • Overall characteristics of FTD
  • Genes involved in frontotemporal dementia
  • Pathology of frontotemporal dementia
  • FTDP-17: 3R and 4R-tauopathies
  • FTLD-TDP subtypes
  • MAPT as the gene for FTD with tangles
  • The microtubule associated protein tau
  • Mutations affecting tau protein in FTD
  • PGRN mutations as a cause for FTD
  • A major locus for FTD and ALS on chromosome 9
  • Chromosome 3 dementia
  • Making sense of these genes
Play 'Presynaptic plasticity'
Presynaptic plasticity More info
Prof. Robert S. Zucker

TOPICS COVERED IN THIS TALK

  • What is short-term synaptic plasticity?
  • Use of quantal analysis to show that plasticity arises presynaptically
  • Synaptic depression and the "Depletion Model"
  • Relationship of depletion model parameters to binomial statistical parameters
  • Refinements to the depletion hypothesis
  • Origin of slow phases of depression
  • Role of multiple vesicle pools
  • Role of vesicle endocytosis
  • Role for calcium in recovery
  • Why depression is sometimes absent
  • Other forms of depression
  • Phases of synaptic enhancement: facilitation, augmentation, and potentiation
  • Presynaptic electrical events in synaptic enhancement
  • Calcium and the nonlinear summation single site hypothesis
  • Kinetic components of calcium removal
  • Multiple sites of calcium action
  • Problems with identifying molecular mediators
  • Candidate molecular mediators
  • A comprehensive model of presynaptic plasticity
  • Other forms of synaptic enhancement
  • Computational roles of short-term synaptic plasticity
  • Physiological roles of short-term synaptic plasticity

TESTIMONIALS

"This is truly the future now. The lectures are so concise and informative, and an excellent teaching tool."
Prof. Virginia Sanders
The Ohio State University, USA

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