Henry Stewart Talks

The Biomedical & Life Sciences Collection

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Biomedical & Life Sciences: All Series

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SERIES IN THIS COLLECTION

A
Advances in Asthma
New mechanisms, management strategies and treatments
Advances in Chronic Obstructive Pulmonary Disease (COPD)
New mechanisms, management strategies and treatments
Agricultural Genetics
Understanding and improving plants and animals for food and agriculture
Alzheimer's Disease
Neurobiology, pathology and treatment
Antibiotic Resistance
From genes to global prevalence
Antivirals
Latest Developments and Future Progress
Apoptosis
Fundamentals, Pathways, Clinical Applications and Role in Disease
Applied Pharmacometrics
Autism and Autism Spectrum Disorders
History, Diagnosis, Neurobiology, Treatment and Outcome
Autoimmunity
Etiology, pathogenesis, clinical manifestation and diagnostic methodologies
B
Biology and Significance of Plasmids
A multi-talk discussion of extrachromosomal elements in microorganisms
Biomarkers
The path forward to highly sensitive and specific molecular diagnostics
The Blood-Brain Barrier
Understanding the regulatory gatekeeper between brain and body
C
Calcium Signaling I
Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances
Calcium Signaling II
Calcium and Disease
Cancer Pain Management
Advancing towards optimal symptom management
Cancer Therapy
Latest thinking in efficacy and toxicity
The Cell Division Cycle
Controlling when and where cells divide and differentiate
Cells of the Innate Immune System
Roles in health and disease
Cerebrovascular Disease
Diagnosis, Treatment and Prevention - a prioritized approach
Chemical Biology
The role of Chemistry in our fundamental understanding of Biology
Chloroplast
The Organelle that Sustains Us
Clinical Proteomics
Cognitive Neuroscience
Emergence of mind from brain
Copy Number Variation
Expanding the repertoire of genetic alterations in studies of natural variation and disease
Cytokines
Intercellular mediators regulating host defense
D
Diabetes in Perspective
DNA Methylation
Physiology, pathology and disease
Drug Metabolizing Enzymes
Fundamentals, Study Methods, Recent Advances and Clinical Significance
E
The Endoplasmic Reticulum
Fundamentals and Role in Disease
Epigenetics
Concepts, Theories, Paradigms and Mechanisms
Epigenetics, Chromatin, Transcription and Cancer
Epilepsy and Seizures
Causation, diagnosis and management
Eukaryotic Gene Regulation
From Chromatin to Transcription to mRNA Processing
Evolution and Medicine
How New Applications Advance Research and Practice
F
Free Radicals and the Oxygen Paradox
Oxidative Stress in Biology, Aging and Disease
From DNA to Proteins
The Multiple Levels of Regulation
G
Gastroenterology and Hepatology
Pathophysiology, presentation, diagnosis and management
Gene-Environment Interactions
Role in the Modulation of Pulmonary and Autoimmune Disease Risks
Genetic Epidemiology I
Fundamentals, Theory, Practice and Latest Developments
Genetic Epidemiology II
Latest Developments
Genetics of Cardiovascular Disease
Genetic interactions in a multifactorial disease
Glycobiology
The discovery of glycan function and its fundamental applications
Good Laboratory Practice
Principles, Compliance and Mutual Recognition
H
Human Population Genetics
Evolution and Variation
I
Innate Immunity
Host recognition and response in health and disease
Introduction to Cheminformatics
Data management, manipulation and properties
Introduction to Human Genetics
Fundamentals and latest advances
Ion Channels
Mediators of ion currents across cell membranes
L
The Legacy of Drosophila Genetics
From 'defining the gene' to 'analyzing genome function'
Libraries in a Digital Age  Full series access
Fundamentals and latest thinking
M
Macrophage Heterogeneity and Function
Role in innate and adaptive immunity
The Mechanisms of Ribosome Function
Insights into protein synthesis
Medical Imaging
Imaging Techniques for Pre-clinical and Clinical Applications
Microarrays
Their design and use
Microbiota
Agents for Health and Disease
Mitochondrial Biogenesis
Processes, Regulation, Functions and Disease
Molecular Basis of Bacterial Infection
Virulence factors of pathogenic bacteria and how they work
Molecular Chaperones
Principles and Diseases
Monoclonal Antibodies as Therapeutic Agents
Fundamentals, Therapeutic Applications and Latest Advances
N
Natural Killer Cell Biology
Natural killer cell-mediated immunity to pathogens and cancer
Neurodegenerative Diseases
Fundamentals, Research Methods, Latest Advances
Neurotrauma
Basic research, clinical care and patients' perspectives
Non-Clinical Testing for Toxicity of Pharmaceuticals
Regulatory and Practical Standards for Testing and Application
O
Obesity
Epidemiology, Etiology, Consequences and Treatment
P
Pain and the Control of Pain
Pain transmission, regulation and management
Pharmaceutical Marketing
Latest insights, challenges, solutions and trends
Physiology and Pathophysiology of Neuroglia
Roles in health and disease
Prions and Amyloids
Self-propagating protein structures in mammals, yeast and fungi
Protein Epidemiology
Understanding Human Diseases at the Level of Protein Structure and Function
Protein Folding, Aggregation and Design
Concepts, Experiments, Theories and Mechanisms
Protein Homeostasis
Folding proteins and maintaining the protein-protein interaction networks
Protein Phosphorylation
A mechanism for regulating most aspects of cell life
Psychopharmacogenetics
Genetic Factors Influencing the Kinetics and Dynamics of Psychotropic Drugs
R
Retroviruses
Biology, Pathogenic Mechanisms and Treatment
RNA Interference
Principles and Applications
S
T
Topical Talks
Talks of interest in the biomedical and life sciences
U
V
Vector-Borne Diseases
Characterization and epidemiology of arthropod transmitted infections
Viruses and Viral Diseases
Emerging threats to humans and animals
W
The World of Hormones
Molecular and Physiological Insights
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FREE TALK OF THE MONTH

Play 'Is there a role for academia in drug discovery'
Is there a role for academia in drug discovery More info
Dr. Adrian J. Ivinson

TOPICS COVERED IN THIS TALK

  • Increasing numbers of neurological disorders correlates with the growing numbers of elderly
  • Paucity of drugs that treat these neurological disorders
  • Reasons for this failure
  • Need to reassess the traditional division of labor between the for-profit sector and the not-for-profit academic sector
  • Transfer of the discovery phase to academia?
  • Other aspects of the heretofore-failed neuro drug discovery pipeline e.g. large-scale genetic studies aimed at unearthing new targets
  • The need to redefine the precompetitive space
  • The need to build new collaborations between companies, and between the commercial and academic sectors

POPULAR TALKS

Play 'A paradigm shift in the brain-immune relationships: Infiltrating macrophages in central nervous system repair'
A paradigm shift in the brain-immune relationships: Infiltrating macrophages in central nervous system repair More info
Prof. Michal Schwartz

TOPICS COVERED IN THIS TALK

  • The CNS immune enigma
  • CNS response to injury
  • Recruitment of macrophages is insufficient
  • Site, dose, timing for macrophage implantation
  • Local and systemic immune response
  • Circulating T cells are needed for recovery
  • Protective autoimmunity vs. autoimmune disease
  • Two faces of macrophages
  • Creation of chimeric mice with head protection
  • Macrophages play anti-inflammatory role
  • Transferred monocytes promote repair
  • T-cells boost monocyte recruitment
  • Macrophages resolve microglia response
  • The glial scar regulates microglia / macrophages
  • CSPG production and degradation
  • CSPG and the IL-10 expressing monocytes
  • Co-localization of macrophages with the glial scar
  • Location determines macrophage phenotype
  • Macrophages and neuroprotection in the retina
  • Macrophages support progenitor cell renewal
  • Monocyte recruitment is limited
  • Type, phenotype, location, timing
  • Neurogenesis: highest manifestation of plasticity
  • CNS specific autoreactive T cells
  • Spatial memory
  • The immunological malfunction
  • Immunity to self and self-maintenance
  • Local and systemic inflammation
  • Circulating cells fight local inflammation
  • Recruitment of monocytes in Alzheimer
  • From immune deficiency to brain malfunction
Play 'Physiology of innate immunity'
Physiology of innate immunity More info
Prof. Keith W. Kelley

TOPICS COVERED IN THIS TALK

  • The varied roles innate immune cells play in physiology of the entire body
  • The role of mononuclear myeloid cells in immunophysiology
  • Neuroendocrine stress responses
  • Appetite
  • Fever
  • Sleep
  • Cognition
  • Pain and sickness
  • Depression
Play 'Ca2+, the endoplasmic reticulum and cardiac pathology'
Ca2+, the endoplasmic reticulum and cardiac pathology More info
Prof. Marek Michalak

TOPICS COVERED IN THIS TALK

  • Molecular studies on the endoplasmic reticulum (ER) function and ER associated chaperones including calreticulin
  • ER-associated functions are crucial in cardiac physiology and pathology -ER stress responses
  • ER calcium buffering proteins impact many cardiac functions including cardiogenesis, ischemia and reperfusion, cardiomyopathies and heart failure