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1. Introduction
2. Talk outline
3. The immune response in tuberculosis
4. Protective factors in the immune response to Mtb
5. Protection or pathogenesis: T cells in TB
6. Protection or pathogenesis: cytokines in TB
7. Protection or pathogenesis: resistant/susceptible
8. Mtb: resistant & susceptible mouse models
9. Factors that regulate host responses in TB
10. Potential regulatory roles for IL-10 in Mtb
11. Suggestive roles for IL-10 in human TB
12. IL-10 in mouse models of TB: conflicting reports
13. Enhanced IL-10 production in "susceptible" mice
14. Experimental overview
15. IL-10 is produced in the lung during Mtb infection
16. Mtb in the absence of IL-10 in BALB/c mice
17. Mtb H37Rv infection in the absence of IL-10
18. Enhanced protection to Mtb: IL-10 & Th1 response
19. IL-10 in immune regulation during Mtb infection
20. The human immune response in tuberculosis
21. Tuberculosis: a major human threat (epidemiology)
22. Difficulties in dealing with tuberculosis
23. Tuberculosis: a major human threat (Dx and Tx)
24. 2 billion people have "latent tuberculosis"
25. "Latent TB" into active TB: no test
26. Transcriptional signatures (latent vs. active TB)
27. Study design
28. Blood reflects cell migration throughout body
29. London the tuberculosis capital of Europe
30. Active vs. latent TB: distinct transcriptional profile
31. 393 transcripts derived from statistical filtering
32. Blood transcriptional signature validation (London)
33. TB is a global disease
34. Outliers in Latent and Active Tuberculosis
35. Transcriptional signature in active TB (London)
36. Active TB signature correlates with radiography
37. Active TB signature is diminished on treatment
38. TB signatures for treatment monitoring
39. Transcriptional modules
40. Finding common clusters across diseases
41. Classical versus modular approach
42. Modular signature of active TB: UK vs. SA (1)
43. TB signature distinct from other diseases
44. Modular signature of active TB: UK vs. SA (2)
45. IFN-inducible genes present in active TB patients
46. Bacterial pathogens can induce IFN production
47. Type 1 IFN can down-regulate IFN-gamma receptor
48. Mtb infection and type 1 IFN
49. Human disease and experimental models
50. Acknowledgements
51. Collaborators
52. The MRC National Institute for Medical Research
53. The Francis Crick institute

Topics Covered

• Tuberculosis (TB) as a major human threat
• T cells & cytokines in TB
• Difficulties in dealing with TB
• Resistant & susceptible TB mouse models
• Potential regulatory roles for IL-10 and factors that regulate host responses in TB
• "Latent TB" into active TB and distinct transcriptional signatures
• Finding common transcriptional clusters across diseases
• TB and type 1 IFN: Bacterial pathogen induction of IFN production and IFN-inducible genes present in active TB patients

Links

Series:

• Cytokines

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

O’Garra, A. (2012, December 27). Regulation of the immune response to pathogens 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 8, 2025, from https://doi.org/10.69645/VVCD8426.
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Publication History

• Published on December 27, 2012

Financial Disclosures

• Prof. Anne O’Garra has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.