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Printable Handouts
Navigable Slide Index
- Introduction
- B cells in autoimmune diseases
- B cell development
- Histopathology
- B cell tolerance checkpoints in autoimmune disease
- B cell activating factor (BAFF) (1)
- B cell activating factor (BAFF) (2)
- B cell activating factor (BAFF) (3)
- CD40/CD40L (1)
- CD40/CD40L (2)
- Toll-like receptors (1)
- Toll-like receptors (2)
- Toll-like receptors (3)
- CD19
- Thymic B cells (1)
- Thymic B cells (2)
- Histopathology of B cells in autoimmune diseases
- Tissue-infiltrating B cells (1)
- Tissue-infiltrating B cells (2)
- Tissue-infiltrating B cells (3)
- Antibody-dependent B cell functions in autoimmune diseases (1)
- Antibody-dependent B cell function
- Antibody-dependent B cell function (IgG) (1)
- Antibody-dependent B cell function (IgG) (2)
- Antibody-dependent B cell function (IgG) (3)
- Antibody-dependent B cell function (IgM)
- Antibody-dependent B cell function (Mem B)
- Antibody-dependent B cell functions in autoimmune diseases (2)
- Antigen presentation
- Cytokine production
- Lymphotoxin
- IL-6 (1)
- IL-6 (2)
- IL-6 (3)
- GM-CSF (1)
- GM-CSF (2)
- Interferon gamma (1)
- Interferon gamma (2)
- Regulatory B cells (1)
- Regulatory B cells: subsets of B cells (1)
- Regulatory B cells: subsets of B cells (2)
- Regulatory B cells (2)
- Regulatory B cells: IL10 production and disease progression
- Regulatory B cells: drug screening
- Regulatory B cells: IL-35-producing B cells
- Regulatory B cells: IL-21-producing B cells
- Targeting B cells in autoimmune diseases
- B cell depletion therapy (1)
- B cell depletion therapy (2)
- B cell depletion therapy (3)
- Immune checkpoints therapy (1)
- Immune checkpoints therapy (2)
- Immune checkpoints therapy (3)
- Acknowledgements
Topics Covered
- B cell development
- B cells in autoimmune diseases
- BAFF
- CD40
- Thymic B cells
- Antibody-dependent B cell functions
- Antigen presentation
- Cytokine production
- IL6
- Regulatory B cells
- B cell depletion therapy
- Immune checkpoints therapy
Links
Series:
- The Immune System - Key Concepts and Questions
- Periodic Reports: Advances in Clinical Interventions and Research Platforms
Categories:
Therapeutic Areas:
Talk Citation
Lin, X. (2023, October 31). B cells at the crossroads of autoimmune diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/5436/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Xiang Lin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
Please wait while the transcript is being prepared...
0:00
Hello everyone. I'm Lin Xiang
from School of Chinese Medicine,
the University of Hong Kong.
Today
I'd like to talk about the roles
of B cells in the
auto immune diseases.
0:13
The simplified immune response
against auto antigens.
The B cells receive
the stimulants,
via B cell receptor,
present antigen to cognate
T cells and then further promote
the T cell differentiation by
costimulatory molecules and
the cytokine production.
Well, these B cells, however,
mature into auto antibody
producing plasma cells.
This cascade happens through
the disease progression.
Now, extensive studies
have suggested
a central role of B cells in
the auto immune pathogenesis.
Because loss of B cell tolerance
can result in increased
serious levels of
auto antibodies and enhanced
effective T cell response and
tissue damages in patients.
Today we'll walk
through the overview of
these regulated B cell responses
in the development
of auto immunity.
1:03
As you can see, the
B cell tolerance
is established
throughout the B cell
developmental stages
in both bone marrow
and the peripheral
ligand organs,
from the prob-B,
pre-B cell stages and
then they will migrate
into the periphery,
and then become
immature B cells.
Through the maturation and
the differentiation stages,
while part of the plasma
cell will migrate
back to the bone marrow
through chemotaxis.
Although approximately
55-75 percent
early immature B cells will
exhibit self reactivity,
most of the other
reactive B cells are
eliminated by multiple
checkpoints accordingly,
which we will explain
in later slides.
Histopathologically, the
massive B cells are detected in