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1. Introduction
2. Criteria for diagnosis of AILD
3. Autoimmune Hepatitis (AIH)
4. Spectrum of AIH in 2008
5. Differential diagnosis: AIH
6. Drugs inducing an AIH-like syndrome
7. Diagnosis of Wilson disease Leipzig score
8. Steps in management of AIH
9. Simplified criteria for diagnosis of AIH
10. When to question initiation of AIH treatment
11. Screening before IST for AIH
12. Indication for AIH treatment
13. AIH: response to immunosuppressive therapy
14. Treatment regiments for adults
15. Standard therapy : AIH
16. AIH: preventative measures while on treatment
17. Monitoring required during IST for AIH
18. AIH: remission following therapy
19. Remission following IST withdrawal
20. AIH: maintenance therapy with Azathioprine
21. Treatment failure
22. Primary & secondary sclerosing cholangitis
23. Potential pathogenesis: sclerosing cholangitis
24. Magnetic Resonance Cholangiography
25. Role of ERCP in PSC
26. PSC: Presenting Features
27. Ulcerative colitis: link to PSC
28. PSC with Inflammatory Bowel Disease (IBD)
29. Survival IBD vs. IBD+PSC
30. Causes of death in 45 patients: PSC
31. RCT: Ursodeoxycholic acid - PSC
32. Why medical therapy fails in PSC?
33. Recurrent AILD after OLT
34. Primary Biliary Cirrhosis (PBC)
35. PBC- physical presentation
36. Typical presentation of PBC in 2009
37. Meta analysis: RCT in UDCA for PBC
38. Liver transplant
39. Longterm survival in early PBC
40. Survival in PBC +/- Biochemical response
41. Survival according to PHG score
42. PBS: natural history
43. Treatment response and histological change
44. Complications of PBC
45. What is the drive and the trigger?
46. PBC cases in first degree relatives
47. PBC: genome wide analysis
48. The genetic web of autoimmunity
49. Acknowledgments

Topics Covered

• Diagnosis of Autoimmune Liver Disease (AILD)
• Diagnosis of Autoimmune Hepatitis (AIH)
• Steps in management of AIH
• AIH treatment
• Response to immunosuppressive therapy in AIH
• Monitoring during IST for AIH
• Remission following therapy in AIH
• Presenting features of primary & secondary Sclerosing Cholangitis (PSC)
• Ulcerative colitis: link to PSC
• PSC with Inflammatory Bowel Disease (IBD)
• Causes of death in PSC
• PSC treatment
• Medical therapy failure in PSC
• Typical presentation of Primary Biliary Cirrhosis (PBC)
• Liver transplant in PBC vs. PSC
• Survival in PBC
• Treatment response and histological change in PBC
• Complications of PBC

Links

Series:

• Gastroenterology and Hepatology

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Gastroenterology & Nephrology
• Immunology & Inflammation

Talk Citation

Publication History

• Published on January 30, 2011

Financial Disclosures

• Dr. Jenny Heathcote has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.