Prions represent a new biological paradigm of protein-mediated information transfer
Prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies (TSEs)
Many unresolved issues remain including the exact molecular nature of the prion, the detailed mechanism of prion propagation, and the mechanism by which prion diseases can be both genetic and infectious
The factors governing the transmission of prions between species remain unclear, in particular the means by which prion strains and PrP primary structure interact to affect inter-species prion transmission
Dramatic advances in our understanding of prions have occurred because of their transmissibility to experimental animals and the development of transgenic (Tg) mouse models has done much to further our understanding about various aspects of prion biology
Telling, G. (2008, September 4). Transgenic mouse models of prion diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 13, 2019, from https://hstalks.com/bs/953/.
Published on September 4, 2008
Prof. Glenn Telling has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.