Chemical synthesis of peptides and peptide libraries

Published on August 14, 2008   41 min

Other Talks in the Category: Methods

0:00
In this presentation, we will discuss the chemical synthesis of peptides and peptide libraries with special emphasis on the advantages of peptides and peptidomimetics for exploring many critical aspects of chemical biology, especially as it relates to structural and biological function.
0:19
Peptides and proteins are of central importance to all biological processes. Therefore, methods for their synthesis by chemical means are of central importance to all aspects of understanding chemical biology. Excellent methods are available for the chemical synthesis of peptides and peptidomimetics and have been developed to a very robust nature over the last 100 years. In fact, peptide synthesis is perhaps the most robust of all synthetic organic methods to prepare classes of organic compounds. The primary focus of this discussion therefore will be on the synthesis of peptides and peptidomimetics that have desired biological properties which are useful for biological applications.
1:05
Why peptides and proteins? Well, basically, because they do everything in biology. They are the class of organic molecules that have been chosen to do all of the necessary chemical processes which are important for biological life. For example, they serve as the catalyst in all of the biological processes and the structural scaffolds of most living systems. They are the mediators of energy transduction, so the messengers and modulators of information transduction it both peripheral and central nervous system. They can readily adapt their structures to recognize other structures. They can readily incorporate all of the periodic chart into their structures and also all of the biosphere into their structures. They readily could change their three-dimensional structure in response to their environment. They have universal application to all biological processes. There are some misconceptions about peptides as suitable drug candidates.
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Chemical synthesis of peptides and peptide libraries

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