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- Design
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1. An introduction to randomization for clinical trials 1
- Prof. William Rosenberger
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2. An introduction to randomization for clinical trials 2
- Prof. William Rosenberger
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3. Randomisation, blinding and drug supply in interactive voice response trials
- Mr. Damian McEntegart
- Analysis
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4. Design and conduct of non-inferiority trials
- Prof. Valerie Durkalski-Mauldin
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5. Nonparametric covariate adjustment
- Prof. Michael Akritas
- Theory
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6. Historical and ethical issues in trial design
- Dr. J. Rosser Matthews
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7. Likelihood ratios and the strength of statistical evidence
- Prof. Jeffrey Blume
- Randomization, Masking and Allocation Concealment
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9. Detection of and adjustment for selection bias in randomized controlled clinical trials
- Prof. Lieven Nils Kennes
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10. Innovative and effective subject randomization methods
- Prof. Wenle Zhao
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11. Selection bias in studies with unequal allocation
- Dr. Olga M. Kuznetsova
- Archived Lectures *These may not cover the latest advances in the field
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12. Design and conduct of equivalence trials
- Prof. Valerie Durkalski-Mauldin
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13. Dose-finding trials in oncology
- Prof. Anastasia Ivanova
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14. Allocation concealment, prediction and selection bias
- Prof. David Torgerson
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15. Pseudo cluster randomization
- Dr. George Borm
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16. Introduction to flexible, adaptive trial design
- Dr. Cyrus Mehta
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17. Randomization in clinical trials
- Prof. William Rosenberger
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18. Novel methods for randomizing
- Dr. William Grant
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19. Permutation tests
- Dr. YanYan Zhou
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21. Multiple analyses in clinical trials
- Prof. Lemuel Moye
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22. Handling of missing data in clinical trials
- Dr. Linda Yau
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24. N-of-1 randomized clinical trials
- Prof. Patrick Onghena
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- The single case controlled observations history
- A long history with influential applications (1)
- A long history with influential applications (2)
- A long history with a growing impact
- N-of-1 RCT definition
- The funnel approach to measurement (1)
- The funnel approach to measurement (2)
- The randomized experimental approach
- Two types of designs
- Phase design
- Alternation design
- Two types of replication
- Simultaneous replication design
- Sequential replication design
- How to randomize and analyze?
- Random assignment in phase designs
- Graphic demonstration of random assignment
- Phase design: numerical example (1)
- Phase design: numerical example (2)
- Random assignment in alternation designs (1)
- Random assignment in alternation designs (2)
- Alternation design: numerical example
- Simultaneous replication design (1)
- Simultaneous replication design (2)
- Sequential replication design (1)
- Sequential replication design (2)
- Validity of N-of-1 RCTs
- External validity of N-of-1 RCTs
- Conclusion
- References (1)
- References (2)
- References (3)
- References (4)
Topics Covered
- History and impact of N-of-1 RCTs
- Distinguishing N-of-1 RCTs: case studies and time series research
- The funnel approach to measurement
- The randomized experimental approach
- Types of N-of-1 designs and replications
- How to randomize and analyze
- Validity of N-of- 1 RCTs
Links
Series:
Categories:
Talk Citation
Onghena, P. (2007, October 1). N-of-1 randomized clinical trials [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2024, from https://hstalks.com/bs/555/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Patrick Onghena has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.