• Defining Retroviruses
• 38 min
  1. An introduction to retroviruses: replication strategy and genetics

  • Dr. Jonathan Stoye
• 45 min
  2. Bovine leukemia virus

  • Prof. Arsene Burny
  • Dr. Lucas Willems
• The First Human Retroviruses
• 65 min
  3. The discovery of human retroviruses and how they cause disease

  • Prof. Robert Gallo
• HIV - Peculiarities of its Genome
• 11 min
  4. HIV: peculiarities of its genome

  • Dr. George Pavlakis
• HIV Transmission, Epidemiology and Public Health/Prevention Issues
• 42 min
  5. HIV/AIDS epidemiology, transmission, and risk factors

  • Prof. William Blattner
• 55 min
  6. HIV prevention and public health issues: a global perspective

  • Prof. Sten H. Vermund
• How HIV causes AIDS
• 35 min
  7. How HIV causes disease 1: identification and characterization of HIV

  • Prof. Bruce Walker
• 43 min
  8. How HIV causes disease 2: immune responses to HIV infection

  • Prof. Bruce Walker
• HIV Therapy - Now and the Future
• 34 min
  9. HIV therapy: taking advantage of progress

  • Prof. Paul Volberding
• 39 min
  10. HIV cure: harnessing innate and adaptive strategies

  • Prof. Luis Montaner
• Archived Lectures *These may not cover the latest advances in the field
• 36 min
  11. The first human retroviruses: the human T lymphotropic viruses (HTLVs)

  • Prof. William Hall
• 59 min
  12. HIV preventive vaccines

  • Prof. Andrew McMichael
• 31 min
  13. HIV/AIDS in the developing world: what can we do?

  • Dr. Joseph O'Neill
• 54 min
  14. Human T-cell leukemia virus type 1 (HTLV-1) and adult T-cell leukemia: insights into cellular transformation

  • Prof. Kuan-Teh Jeang
• 41 min
  15. Antiretroviral therapy 2007, new concepts and lessons learned

  • Prof. Robert Redfield
• 29 min
  16. What to do in therapy in the face of HIV drug resistance?

  • Prof. Mark Wainberg
• 42 min
  17. Viral reservoirs, latency and mechanisms of HIV persistence

  • Prof. Robert Siliciano
• 28 min
  18. HIV preintegration complexes

  • Prof. Lee Ratner
• 30 min
  19. The discovery of ATL field expansion in 40 yrs

  • Prof. Junji Yodoi

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Human retroviruses
3. Endemic areas of HTLV-I infection
4. HTLV-I: associated clinical disorders
5. HAM/ TSP
6. ATLL clinical/epidemiological features
7. ATLL pathological and immunological features
8. A flower cell
9. Cutaneous infiltrates in ATLL (1)
10. Cutaneous infiltrates in ATLL (2)
11. Typical histopathological of lymphoma
12. Cell proliferation and transformation by HTLV-I Tax
13. HTLV-I Tax and NF-kappa B activation
14. NF-kappa B activation in patients with ATLL
15. Development of ATLL
16. Established HTLV-I Tax-transgenic mouse models
17. Generation of Tax transgenic mice
18. Summary of initial study of transgenic mice
19. Estimation of Tax DNA copy number
20. Tax integration sites-genome walking analysis
21. Gross pathological findings
22. Histological findings (1)
23. Histological findings (2)
24. Peripheral blood: leukemic cells
25. Histological findings: P. jiroveci pneumonia
26. NF-kappa B activation in Tax Tg mice
27. Transfer of Tg Tax ATLL disorder to SCID mice
28. SCID mice peripheral blood
29. SCID mice histology
30. Flow cytometry analysis
31. Effect of lck promoter on T-cell phenotype
32. Affymetrix microarray data
33. Conclusions (1)
34. HTLV-II infection in American Indian populations
35. HTLV-II infection in IDUs
36. HTLV-II phylogenetic tree
37. HTLV Tax heterogeneity
38. HTLV-II molecular epidemiology
39. HTLV type II: oncogenic properties of Tax
40. Conclusions (2)

Topics Covered

• Human retroviruses
• HTLV-1
• HTLV-2
• Epidemiology of infection
• Clinical features of infection
• Adult T-cell leukemia/lymphoma (ATLL)
• Molecular pathogenesis of ATLL
• Transgenic mouse model of ATLL

Links

Series:

• Retroviruses

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. William Hall has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.