In this talk, we will discuss "The Impact of
Genomic Architecture and Diversity on Infectious Diseases".
The talk will be divided into two parts.
That is, human genomics and viral genomics.
In the first half of this presentation,
I will be discussing about genome architecture in eukaryotes.
Eukaryotic genomes are complex and vary in size over a range of 80,000,
but as is known that in biology,
to every rule there is an exception.
We have paradoxes.
The human appears to be more complex than the butterfly and a simple plant.
The human has 46 chromosomes,
the butterfly 250, and the plant 1,260.
The K-value paradox states that complexity does not correlate with chromosome number.
The human is more complex than the unicellular amoeba,
however, the genome size of a human is much smaller than an amoeba.
Hence the C-value paradox,
complexity does not correlate with genome size.
The human genome has about 28,000 genes,
the mustard genome has about 26,000 genes,
the rice genome has about 50,000 genes.
The human appears to be much more complex than the rice and the mustard.
The N-value paradox states that complexity does not correlate with the number of genes.
The life forms also differ in cell number.