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Printable Handouts
Navigable Slide Index
- Introduction
- Aims of this lecture
- The 5 W’s of antibiotic discovery
- The urgent need (1)
- The urgent need (2)
- The urgent need (3)
- Challenges - cost
- Challenges - time
- Challenges - lifespan
- Antibiotic discovery of the past
- Antibiotic discovery of the more recent past
- Antibiotic discovery of the present
- Antibiotic discovery of the future
- Organisations supporting antibiotic discovery
- Conclusions
- Further reading
- Thank you for listening
Topics Covered
- The history of antibiotics
- Antibiotic resistance
- Antibiotic development
- The need for new antibiotics
- The antibiotic golden age
- Target to drug and drug to target strategies
- Challenges in antibiotic development
- The future of antibiotic discovery
Links
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Therapeutic Areas:
External Links
Talk Citation
Cox, J. (2021, October 28). Strategies for discovering new antibiotics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 14, 2024, from https://doi.org/10.69645/MDEJ7607.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jonathan Cox has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
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0:00
I'm Dr. Jonathan Cox, I'm a senior lecturer in microbiology at Aston University.
In this lecture, I'm going to talk to you about the different strategies for discovering new antibiotics.
0:15
The aims of this lecture are to introduce antibiotic discovery: what it is, who does it,
when they're doing it, where they're doing it, and why they're doing it.
After that, I'm going to discuss 'the urgent need', and explain what that means.
I'm going to highlight the challenges involved in antibiotic discovery,
and I'm going to consider the past, present, and future strategies for antibiotic discovery.
Finally, I'm going to tell you about organisations that are supporting antibiotic discovery.
0:51
Let's look at the five Ws of antibiotic discovery.
The first one is 'what', what is antibiotic discovery?
It's finding new selective medicines to inhibit bacterial growth and survival, in an infected host.
That's a really important point, selective medicine.
We don't want to discover new antibiotics that will not only kill bacteria,
but will also kill the humans that take that drug.
It's really important that those medicines are selective, to inhibit the bacteria and not to inhibit the host.
Who's doing it?
Academia, big pharma, small- and medium-sized enterprises, and massive consortia as well
are involved in antibiotic discovery.
When did we start discovering new antibiotics?
It all started in 1928, when Alexander Fleming first discovered penicillin.
I'll tell you a little bit more about that, and how that point of discovery contributed to 'the urgent need' moving forward.
Where are we trying to discover antibiotics?
'Everywhere' is the answer, this is a global effort, because antibiotic resistance
is something that impacts every single person on the planet,
so it's of paramount importance that we are all looking to try and find new antibiotics,
and trying to move this area of research forward.
Why is it important?
Let me go on to 'the urgent need'.