• Introduction to Genetic Diversity
• 72 min
  1. The sources of genomic diversity

  • Dr. George Nelson
• 27 min
  2. Bioinformatics tools in conservation biology

  • Dr. Mahmood Shivji
  • Mr. Vincent Richards
• Populations, Samples and Biological Databases
• 48 min
  3. Specimen banking: saving for the future

  • Ms. Elaine Gunter
• Bioinformatics and Genome Analysis
• 44 min
  4. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 47 min
  5. Information content in sequences and its relation to protein structure prediction

  • Dr. Rosemarie Swanson
• 40 min
  6. Pattern discovery in bioinformatics

  • Prof. Giri Narasimhan
• Human Disease
• 38 min
  7. Genes in common diseases

  • Prof. Jennie Lou
• 42 min
  8. The impact of genomic architecture and diversity on infectious diseases

  • Prof. Vincent Chow
  • Dr. Meena Sakharkar
• 29 min
  9. The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness

  • Dr. Michel Tibayrenc
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  10. Unity and diversity in microbial genomes

  • Dr. Kishore Sakharkar
• 38 min
  11. Analysis of protein-protein interaction, transcriptional regulation and metabolic networks

  • Dr. Andreas Wagner
• 39 min
  12. Exploring and predicting phenotype and function in cancer biology: working in high dimensional data spaces

  • Prof. Robert Clarke
• 59 min
  13. Widespread structural variations in the human genome

  • Dr. Charles Lee
• 39 min
  14. Human genome variation

  • Dr. Kelly Frazer
• 36 min
  15. Human genetic variation and therapeutic development

  • Dr. Sally John
  • Dr. Nick Davies
• 62 min
  16. Evolving genomic approaches to the study of complex cardiovascular diseases in human populations: genetic and genomic epidemiology

  • Dr. Christopher O'Donnell
• 42 min
  17. Population genetics studies in Africa: curiosity and challenges

  • Prof. Himla Soodyall
• 37 min
  18. Sample collection for human genetics

  • Dr. Michael Dean
• 40 min
  19. Diagnosis of early relapse in ovarian cancer using serum proteomic profiling

  • Dr. Jean Gao

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Elaine W. Gunter - Specimen Solutions, LLC
3. Presentation topics
4. Disclaimer
5. Life in the molecular diagnostic era
6. Pragmatic (but critical) questions
7. More pragmatic questions
8. Gaining access to banked specimens
9. Why consider specimen banking?
10. Genetic research
11. Uses of genetic testing
12. Additional uses of genetic testing
13. Materials can be stored for nucleic acid extraction
14. Optimal blood collection for DNA/RNA extraction
15. Dried blood spots collected on Whatman paper
16. Tissue collection options prior to long-term storage
17. How should specimens be stored?
18. Specimen storage
19. Walk-in storage units of vials, bags or tissues
20. Mechanical freezers for DNA/RNA storage
21. High-capacity vapor-phase liquid nitrogen dewar
22. Examples of multi-aliquot specimen storage
23. Newer forms of storage at ambient temperature
24. Multi-aliquot specimen storage possibility
25. Multi-aliquot specimen storage at -70 to -800C
26. "Cryo Bio System" plastic straw storage system
27. Some of well-known collections/repositories
28. The NCI cancer genome atlas
29. SWAN: study of woman's health across the nation
30. TuBaFrost project
31. NCI's cooperative human tissue network
32. NCI SPOREs
33. Spanish national tumor bank network
34. U.K. Biobank
35. CDBMP
36. What permissions are required?
37. U.S. research on human specimens
38. HIPAA legal obligations protect living subjects
39. Genetic analysis of samples
40. Well-characterized disease genetic markers
41. Additional disease genetic markers
42. Previously developed polymorphism assays
43. DNA microarray chips
44. Current methodologies in molecular diagnostic
45. Polymerase chain reaction (PCR) testing
46. Microsatellite assays
47. Tissue microarrays allow tumor molecular profiling
48. Tissue arrays have wide utility
49. Whole genome amplification
50. The future is now in molecular diagnostics
51. Resource book for repositories and collections
52. NCI guidelines for supported biorepositories
53. ISBER
54. Acknowledgements

Topics Covered

• The rationale for specimen banking
• Recommended practices
• Genetic analyses prior to banking nucleic acids or tissues
• Long-term storage of samples
• Access to the resource
• Analysis of samples
• Choice of markers
• Types and testing of markers
• Major banking programs

Links

Series:

• Using Bioinformatics in the Exploration of Genetic Diversity

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Reviewed on June 1, 2018

Financial Disclosures

• Ms. Elaine Gunter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.