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- 2023
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1. Planning and response to COVID-19: lessons from China and South-East Asia
- Prof. Annelies Wilder-Smith
- 2022
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2. The emergence of the SARS-CoV-2 Omicron variant
- Prof. Emma Thomson
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3. How is Omicron different?
- Prof. Emma Thomson
- 2021
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5. Potential of ‘long-COVID’ in triggering chronic co-pathologies
- Dr. İmdat Eroğlu
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6. SARS-CoV-2 monoclonal antibody testing in vivo
- Prof. Michael Diamond
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7. mRNA COVID-19 vaccine efficacy in recovered vs COVID-naive individuals
- Prof. E. John Wherry
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8. SARS-CoV-2 variants: implications for immunity and vaccine development
- Prof. Danny Altmann
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10. SARS-COV-2 human monoclonal antibody therapy update
- Prof. James Crowe
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11. Emergence of blood clotting disorders resulting from COVID vaccines inoculations
- Prof. Dr. Sabine Eichinger
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12. SARS-CoV-2 evolution within and between individuals
- Prof. Katia Koelle
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13. Identifying SARS-CoV-2 proteases
- Prof. Dr. Christa E. Müller
- Prof. Dr. Michael Gütschow
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14. Genetic surveillance and the emergence of SARS-CoV-2 variants
- Prof. Emma Thomson
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15. The COVID-19 outbreak: April 2021 update
- Prof. Jonathan Temte
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16. ABO blood groups and SARS-CoV-2 susceptibility
- Dr. Sean Stowell
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17. Impact of COVID-19 on neuropsychiatric disorders and mental health
- Prof. Anthony David
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18. The immune system response to the SARS-CoV-2 virus: March 2021 update
- Prof. Paul Klenerman
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23. SARS-CoV-2 vaccine rollout campaigns
- Prof. Luis Graca
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25. Interspecies transmission of SARS-CoV-2
- Dr. Dalan Bailey
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26. Complement activation in COVID-19
- Prof. Jeffrey Laurence
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27. Human movement patterns and local spread of COVID-19
- Prof. Ben Cowling
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28. SARS-CoV-2 mutations: phenotypes and implications for vaccine development
- Prof. David Montefiori
- 2020
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29. The immune system response to the SARS-CoV-2 virus: December 2020 update
- Prof. Paul Klenerman
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30. Triage and end of life care planning in COVID-19
- Prof. Robin Taylor
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31. Natural killer cells as COVID-19 therapy
- Dr. Philippa Kennedy
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32. Update on the SNG001 drug, an INFβ therapy for COVID-19
- Prof. Stephen Holgate
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34. Identification of a new coronavirus-specific RNA export protein complex
- Dr. Montse Bárcena-Martin
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35. The neurological symptoms of COVID-19
- Dr. Michael Zandi
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36. Imperial College London’s saRNA Vaccine - COVAC1
- Dr. Katrina Pollock
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37. Interferon-α2b as a therapy for COVID-19
- Prof. Eleanor N. Fish
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38. Potential long-term health effects of a SARS-CoV-2 infection
- Prof. Danny Altmann
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39. The COVID-19 coronavirus outbreak: October 2020 update
- Prof. Jonathan Temte
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41. Rheumatic diseases and COVID-19
- Dr. Zachary Wallace
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42. The cardiovascular complications of SARS-CoV-2 infection
- Prof. Srihari Naidu
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43. Medical wearable devices for tracking symptoms of COVID-19
- Prof. John Rogers
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44. Risk of re-emergence of COVID-19 after exit from lockdown
- Dr. Leonardo Lopez
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45. The evolutionary origin of SARS-CoV-2
- Dr. Feng Gao
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46. Predicting COVID-19 outbreaks by measuring SARS-CoV-2 RNA in sewage sludge
- Prof. Jordan Peccia
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47. Approaches for elucidating genetic susceptibility to SARS-CoV-2
- Dr. Kenneth Baillie
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48. The immune system response to the SARS-CoV-2 virus: July 2020 update
- Prof. Paul Klenerman
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49. The impact of COVID-19 in the elderly and in care homes
- Dr. David Strain
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50. Human challenge trials for vaccines against COVID-19
- Prof. Peter Smith
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51. The development of SARS-CoV-2 vaccines
- Prof. Peter Hotez
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52. Convalescent plasma therapy as a treatment for COVID-19
- Dr. Manu Shankar-Hari
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53. Remdesivir COVID-19 clinical trial
- Prof. Mahesh Parmar
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54. Nanotechnologies in the fight against coronaviruses
- Prof. Sabine Szunerits
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55. The COVID-19 coronavirus outbreak: May 2020 update
- Prof. Jonathan Temte
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56. INFβ therapy for COVID-19: the new SNG001 drug
- Prof. Stephen Holgate
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57. Strategies for exiting the lockdown
- Prof. David McCoy
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58. SARS-CoV-2 human monoclonal antibody therapy
- Prof. James Crowe
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59. An FDA approved salivary test for SARS-CoV-2 infection
- Prof. Andrew Brooks
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60. Development of an intranasal vaccine for SARS-CoV-2
- Dr. Scot Roberts
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61. The immune system response to the SARS-CoV-2 virus: an update
- Prof. Paul Klenerman
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62. A novel AIOD-CRISPR system for diagnosis of SARS-CoV-2
- Prof. Changchun Liu
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63. Development of PRO-140 (Leronlimab) as a treatment for COVID-19
- Dr. Jacob Lalezari
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64. COVID-19 epidemiology and potential treatments: follow up interview
- Prof. Ralph Baric
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65. SARS-CoV-2 vaccine development: where are we now?
- Prof. Gary Kobinger
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66. SARS-CoV-2: What we need to know and possible future therapies
- Prof. Stanley Perlman
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67. SARS-CoV-2 vaccine: current biological targets and considerations
- Dr. Adolfo Garcia-Sastre
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68. The current understanding of the biology of the SARS-CoV-2 virus
- Prof. Peter Palese
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70. The immune system response to the SARS-CoV-2 virus
- Prof. Paul Klenerman
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71. SARS-CoV-2 vaccine development
- Prof. Stanley Plotkin
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72. The COVID-19 outbreak: an update on the SARS-CoV-2 virus
- Prof. Ralph Baric
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73. The COVID-19 coronavirus outbreak: a current view
- Prof. Jonathan Temte
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74. The COVID-19 coronavirus outbreak: March 2020 update
- Prof. Jonathan Temte
Topics Covered
- Status and efficiency of SARS-CoV-2 genetic surveillance in the USA
- The identification of a ‘Californian’ variant, Epsilon, following a surge in Covid-19 cases in California in early 2021
- The genetic characteristics of the Epsilon variant and the phenotypic advantages they provide
- The more recent identification of a separate variant from India, the Delta variant: key characteristics and their implications
Biography
Professor Eric Vail received his MD from St. George’s University SOM after which he completed AP/CP Residency at New York Medical College and an MGP Fellowship at Cedars-Sinai Medical Center. He is currently the Director of Molecular Pathology at Cedars-Sinai Medical Center. His laboratory offers a wide array of molecular tests, focusing primarily on clinical tumor sequencing and COVID testing. Current research interests focus on the application of genomic findings in clinical oncology. Since the COVID-19 pandemic, his team has also utilized viral whole-genome sequencing to investigate SARS-CoV-2 genomics, transmission patterns and variants.
Links
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Talk Citation
Vail, E. (2021, June 18). SARS-CoV-2 evolution: emergence of the ‘Californian’ and ‘Indian’ variants [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/4683/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Eric Vail has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Respiratory Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Interviewer: Professor Eric Vail, thank you very much for
taking the time to do this interview with us today, to discuss
the emergence of new viral phenotypes, of
the new Californian and Indian SARS-CoV-2 variants in particular.
First of all, what is the status of SARS-CoV-2 genetic surveillance in the USA today,
as well as more specifically in California?
Prof. Vail: Significantly better than it used to be.
You can look back towards the beginning of this year or even before that,
and we're talking about a couple of thousand sequences a week.
Now, especially during the end of May, you're having 10 to 15 times that number,
30/40/50 thousand sequences a week.
I think that there has been a significant ramp up, and
a significant effort to try to really track as much of this virus as possible.
New variant detection needs about five percent of all cases being sequenced.
We were under one percent for a long time, and we're really starting to get to that critical threshold,
especially to where the UK was for quite a long time,
considering that they were over five percent even back in October,
they really had a robust sequencing effort.
Interviewer: What initially prompted you to conduct such extensive screening, of
SARS-CoV-2 viral genomes found in California specifically?
Prof. Vail: We have two different studies that we did, one in the very early days of the pandemic, about March/April of 2020.
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