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- 2023
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1. Planning and response to COVID-19: lessons from China and South-East Asia
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2. The emergence of the SARS-CoV-2 Omicron variant
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3. How is Omicron different?
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5. Potential of ‘long-COVID’ in triggering chronic co-pathologies
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6. SARS-CoV-2 monoclonal antibody testing in vivo
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7. mRNA COVID-19 vaccine efficacy in recovered vs COVID-naive individuals
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8. SARS-CoV-2 variants: implications for immunity and vaccine development
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10. SARS-COV-2 human monoclonal antibody therapy update
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11. Emergence of blood clotting disorders resulting from COVID vaccines inoculations
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12. SARS-CoV-2 evolution within and between individuals
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13. Identifying SARS-CoV-2 proteases
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14. Genetic surveillance and the emergence of SARS-CoV-2 variants
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15. The COVID-19 outbreak: April 2021 update
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16. ABO blood groups and SARS-CoV-2 susceptibility
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17. Impact of COVID-19 on neuropsychiatric disorders and mental health
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18. The immune system response to the SARS-CoV-2 virus: March 2021 update
- Prof. Paul Klenerman
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23. SARS-CoV-2 vaccine rollout campaigns
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25. Interspecies transmission of SARS-CoV-2
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26. Complement activation in COVID-19
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27. Human movement patterns and local spread of COVID-19
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28. SARS-CoV-2 mutations: phenotypes and implications for vaccine development
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29. The immune system response to the SARS-CoV-2 virus: December 2020 update
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30. Triage and end of life care planning in COVID-19
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31. Natural killer cells as COVID-19 therapy
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32. Update on the SNG001 drug, an INFβ therapy for COVID-19
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34. Identification of a new coronavirus-specific RNA export protein complex
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35. The neurological symptoms of COVID-19
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36. Imperial College London’s saRNA Vaccine - COVAC1
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37. Interferon-α2b as a therapy for COVID-19
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38. Potential long-term health effects of a SARS-CoV-2 infection
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39. The COVID-19 coronavirus outbreak: October 2020 update
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41. Rheumatic diseases and COVID-19
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42. The cardiovascular complications of SARS-CoV-2 infection
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43. Medical wearable devices for tracking symptoms of COVID-19
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44. Risk of re-emergence of COVID-19 after exit from lockdown
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46. Predicting COVID-19 outbreaks by measuring SARS-CoV-2 RNA in sewage sludge
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48. The immune system response to the SARS-CoV-2 virus: July 2020 update
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49. The impact of COVID-19 in the elderly and in care homes
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50. Human challenge trials for vaccines against COVID-19
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51. The development of SARS-CoV-2 vaccines
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52. Convalescent plasma therapy as a treatment for COVID-19
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53. Remdesivir COVID-19 clinical trial
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55. The COVID-19 coronavirus outbreak: May 2020 update
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56. INFβ therapy for COVID-19: the new SNG001 drug
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57. Strategies for exiting the lockdown
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58. SARS-CoV-2 human monoclonal antibody therapy
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59. An FDA approved salivary test for SARS-CoV-2 infection
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60. Development of an intranasal vaccine for SARS-CoV-2
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61. The immune system response to the SARS-CoV-2 virus: an update
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66. SARS-CoV-2: What we need to know and possible future therapies
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67. SARS-CoV-2 vaccine: current biological targets and considerations
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68. The current understanding of the biology of the SARS-CoV-2 virus
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70. The immune system response to the SARS-CoV-2 virus
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71. SARS-CoV-2 vaccine development
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72. The COVID-19 outbreak: an update on the SARS-CoV-2 virus
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73. The COVID-19 coronavirus outbreak: a current view
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74. The COVID-19 coronavirus outbreak: March 2020 update
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Topics Covered
- Update on the immune response to SARS-CoV-2
- Current knowledge on the stability of the immune response
- The role of interferon alpha in the response
- The new virus strain in the UK (VUI – 202012/01)
- Research looking into the long-term health issues arising from COVID-19
Biography
Paul Klenerman trained in medicine at Cambridge and Oxford and specialised in infectious diseases. He did his PhD in viral immunology at Oxford University and a postdoc in Zurich before returning to Oxford to establish a lab looking at immune responses to infection. The work includes studies of hepatitis C and a range of viruses affecting the lungs and liver - looking at how these evade the immune response, and the development of vaccines. He is focused especially on novel T cell responses in the mucosal surfaces which are critical for early host defence. He is an NIHR senior fellow and a Wellcome Trust investigator and holds a chair in the Nuffield Department of Medicine in Oxford.
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Talk Citation
Klenerman, P. (2020, December 22). The immune system response to the SARS-CoV-2 virus: December 2020 update [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/4498/.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Respiratory Diseases
Transcript
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0:00
Interview: Professor Klenerman, thank you for doing this update with us today on
the immune system response to the SARS-CoV-2 virus,
your last interview with us on this topic being in July this year.
What are some of the main changes in the understanding of the mechanisms
of how the immune system responds to SARS-CoV-2?
Prof. Klenerman: I think the principles were established reasonably early about the major responses.
I guess in the last few months
there haven't been huge surprises,
but quite a lot of refinement about these responses.
Much more is known about the stability of the responses as
well because we've just had more time to study them, and
of course, many more patients have been studied now.
I think the main messages are still that there's a blunted early innate response,
but later on, in people who are very sick,
the innate response takes over in a very dysregulated way.
Some of the papers have used that word
'dysregulation', it's a coordination of the immune response
later in the disease and seems to be a problem in the people who are sickest, and
there's a bit of debate over whether it's best described as a 'cytokine storm'.
But it's an OK description of something which is quite chaotic,
I think that's probably the point to get across, and that's not unique to COVID
but it is quite striking in these patients.
In some of the white blood cell subsets that are triggered by those cytokines
(the neutrophils, and the myeloid set of cells and monocytes),
there are some quite striking changes.
Then with the lymphocytes, which are more responsive for adaptive immunity,
we know a good deal more about the quality of the neutralizing antibodies,
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