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- 2023
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1. Planning and response to COVID-19: lessons from China and South-East Asia
- Prof. Annelies Wilder-Smith
- 2022
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2. The emergence of the SARS-CoV-2 Omicron variant
- Prof. Emma Thomson
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3. How is Omicron different?
- Prof. Emma Thomson
- 2021
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5. Potential of ‘long-COVID’ in triggering chronic co-pathologies
- Dr. İmdat Eroğlu
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6. SARS-CoV-2 monoclonal antibody testing in vivo
- Prof. Michael Diamond
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7. mRNA COVID-19 vaccine efficacy in recovered vs COVID-naive individuals
- Prof. E. John Wherry
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8. SARS-CoV-2 variants: implications for immunity and vaccine development
- Prof. Danny Altmann
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10. SARS-COV-2 human monoclonal antibody therapy update
- Prof. James Crowe
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11. Emergence of blood clotting disorders resulting from COVID vaccines inoculations
- Prof. Dr. Sabine Eichinger
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12. SARS-CoV-2 evolution within and between individuals
- Prof. Katia Koelle
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13. Identifying SARS-CoV-2 proteases
- Prof. Dr. Christa E. Müller
- Prof. Dr. Michael Gütschow
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14. Genetic surveillance and the emergence of SARS-CoV-2 variants
- Prof. Emma Thomson
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15. The COVID-19 outbreak: April 2021 update
- Prof. Jonathan Temte
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16. ABO blood groups and SARS-CoV-2 susceptibility
- Dr. Sean Stowell
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17. Impact of COVID-19 on neuropsychiatric disorders and mental health
- Prof. Anthony David
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18. The immune system response to the SARS-CoV-2 virus: March 2021 update
- Prof. Paul Klenerman
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23. SARS-CoV-2 vaccine rollout campaigns
- Prof. Luis Graca
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25. Interspecies transmission of SARS-CoV-2
- Dr. Dalan Bailey
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26. Complement activation in COVID-19
- Prof. Jeffrey Laurence
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27. Human movement patterns and local spread of COVID-19
- Prof. Ben Cowling
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28. SARS-CoV-2 mutations: phenotypes and implications for vaccine development
- Prof. David Montefiori
- 2020
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29. The immune system response to the SARS-CoV-2 virus: December 2020 update
- Prof. Paul Klenerman
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30. Triage and end of life care planning in COVID-19
- Prof. Robin Taylor
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31. Natural killer cells as COVID-19 therapy
- Dr. Philippa Kennedy
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32. Update on the SNG001 drug, an INFβ therapy for COVID-19
- Prof. Stephen Holgate
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34. Identification of a new coronavirus-specific RNA export protein complex
- Dr. Montse Bárcena-Martin
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35. The neurological symptoms of COVID-19
- Dr. Michael Zandi
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36. Imperial College London’s saRNA Vaccine - COVAC1
- Dr. Katrina Pollock
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37. Interferon-α2b as a therapy for COVID-19
- Prof. Eleanor N. Fish
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38. Potential long-term health effects of a SARS-CoV-2 infection
- Prof. Danny Altmann
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39. The COVID-19 coronavirus outbreak: October 2020 update
- Prof. Jonathan Temte
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41. Rheumatic diseases and COVID-19
- Dr. Zachary Wallace
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42. The cardiovascular complications of SARS-CoV-2 infection
- Prof. Srihari Naidu
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43. Medical wearable devices for tracking symptoms of COVID-19
- Prof. John Rogers
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44. Risk of re-emergence of COVID-19 after exit from lockdown
- Dr. Leonardo Lopez
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45. The evolutionary origin of SARS-CoV-2
- Dr. Feng Gao
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46. Predicting COVID-19 outbreaks by measuring SARS-CoV-2 RNA in sewage sludge
- Prof. Jordan Peccia
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47. Approaches for elucidating genetic susceptibility to SARS-CoV-2
- Dr. Kenneth Baillie
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48. The immune system response to the SARS-CoV-2 virus: July 2020 update
- Prof. Paul Klenerman
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49. The impact of COVID-19 in the elderly and in care homes
- Dr. David Strain
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50. Human challenge trials for vaccines against COVID-19
- Prof. Peter Smith
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51. The development of SARS-CoV-2 vaccines
- Prof. Peter Hotez
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52. Convalescent plasma therapy as a treatment for COVID-19
- Dr. Manu Shankar-Hari
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53. Remdesivir COVID-19 clinical trial
- Prof. Mahesh Parmar
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54. Nanotechnologies in the fight against coronaviruses
- Prof. Sabine Szunerits
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55. The COVID-19 coronavirus outbreak: May 2020 update
- Prof. Jonathan Temte
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56. INFβ therapy for COVID-19: the new SNG001 drug
- Prof. Stephen Holgate
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57. Strategies for exiting the lockdown
- Prof. David McCoy
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58. SARS-CoV-2 human monoclonal antibody therapy
- Prof. James Crowe
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59. An FDA approved salivary test for SARS-CoV-2 infection
- Prof. Andrew Brooks
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60. Development of an intranasal vaccine for SARS-CoV-2
- Dr. Scot Roberts
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61. The immune system response to the SARS-CoV-2 virus: an update
- Prof. Paul Klenerman
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62. A novel AIOD-CRISPR system for diagnosis of SARS-CoV-2
- Prof. Changchun Liu
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63. Development of PRO-140 (Leronlimab) as a treatment for COVID-19
- Dr. Jacob Lalezari
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64. COVID-19 epidemiology and potential treatments: follow up interview
- Prof. Ralph Baric
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65. SARS-CoV-2 vaccine development: where are we now?
- Prof. Gary Kobinger
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66. SARS-CoV-2: What we need to know and possible future therapies
- Prof. Stanley Perlman
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67. SARS-CoV-2 vaccine: current biological targets and considerations
- Dr. Adolfo Garcia-Sastre
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68. The current understanding of the biology of the SARS-CoV-2 virus
- Prof. Peter Palese
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70. The immune system response to the SARS-CoV-2 virus
- Prof. Paul Klenerman
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71. SARS-CoV-2 vaccine development
- Prof. Stanley Plotkin
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72. The COVID-19 outbreak: an update on the SARS-CoV-2 virus
- Prof. Ralph Baric
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73. The COVID-19 coronavirus outbreak: a current view
- Prof. Jonathan Temte
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74. The COVID-19 coronavirus outbreak: March 2020 update
- Prof. Jonathan Temte
Topics Covered
- The self-amplifying RNA vaccine technology
- Current stage of the clinical trial
- Next steps in the clinical trial
- The future of the vaccine
Biography
Dr Katrina Pollock is a Senior Clinical Research Fellow in Vaccinology and Honorary Consultant at Imperial College London. She is Chief Investigator for the Imperial COVID-19 RNA vaccine trials and Principle Investigator for the Oxford COVID-19 vaccine trials. She read medicine as an undergraduate at Newnham College, University of Cambridge, and then at Imperial College School of Medicine before completing speciality training as a clinician scientist in genitourinary and HIV medicine. She now leads a series of experimental medicine, early phase, and first-in-human trials for the development of novel vaccines against a broad variety of pathogens including HIV, chlamydia, Ebola, malaria, and most recently SARS-CoV-2 infection.
Links
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Talk Citation
Pollock, K. (2020, October 25). Imperial College London’s saRNA Vaccine - COVAC1 [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/4442/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Katrina Pollock has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
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0:00
Interviewer: Doctor Pollock, thank you very much for taking the time today for
this interview on Imperial College London's RNA vaccine.
Could you please give an overview on the molecular basis of the vaccine,
and therefore, how it works?
. Pollock: Thank you for inviting me to talk about
the imperial College COVID-19 vaccine program today.
It's an honour to be here.
I'd like to tell you about the design of the vaccine first of all.
We're using a molecular vaccine which adopts a self-amplifying RNA design.
What that means is that we're using a molecule of RNA,
which once it enters into the cell,
can be amplified and increase the potency of the vaccine.
The way that works is quite complex,
but I can break it down into several different steps.
This is part of a wider global push
to really improve the work that's previously been done in
molecular vaccinology and really test the boundaries of
this technology in order to deliver new vaccines that can respond rapidly to pandemics.
The way that self-amplifying RNA works is that once inside the cell,
it encodes for a protein replicon which is derived from an alphavirus.
That allows the vaccine itself to be replicated,
so you get more copies than just the few that you initially received from the vaccine.
At the same time, within the vaccine,