Registration for a live webinar on 'The role of T cells in COVID from asymptomatic to severe outcomes' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Fundamental aspects
-
1. Inflammation and tissue homeostasis
- Prof. Herman Waldmann
-
2. Introduction to the immune system
- Prof. Herman Waldmann
-
3. Hematopoiesis: the making of an immune system
- Prof. Paul J. Fairchild
-
4. Inflammation: purposes, mechanisms and development
- Prof. Pietro Ghezzi
-
5. Phagocytosis
- Dr. Eileen Uribe-Querol
-
6. Regulated cell death mechanisms and their crosstalk with the immune system 1
- Dr. Luis Alberto Baena-Lopez
-
7. Regulated cell death mechanisms and their crosstalk with the immune system 2
- Dr. Luis Alberto Baena-Lopez
- Innate immunity
-
11. Cells of the innate immune system
- Prof. Kevin Maloy
-
12. Microbial recognition and the immune response
- Dr. Dana Philpott
-
13. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
- Intercellular mediators
-
14. Chemokines
- Dr. James E. Pease
-
15. Cytokines
- Prof. Iain McInnes
-
16. IL-1 family cytokines as the canonical DAMPs of the immune system
- Prof. Seamus Martin
-
17. Glycoimmunology
- Prof. Paula Videira
- Adaptive immunity B cells
-
20. Antigen recognition in the immune system
- Prof. Herman Waldmann
-
21. B cell biology
- Prof. Richard Cornall
-
22. Antibody structure and function: antibody structure
- Dr. Mike Clark
-
23. Antibody structure and function: antibody function
- Dr. Mike Clark
-
24. Antibody genes and diversity
- Dr. Mike Clark
-
25. In vivo antibody discovery and hybridoma technology
- Prof. Dr. Katja Hanack
-
26. Antibody engineering: beginnings to bispecifics and beyond
- Dr. Ian Wilkinson
-
28. The immunobiology of Fc receptors
- Prof. Mark Cragg
-
29. Immunoreceptors
- Prof. Anton van der Merwe
-
30. Affinity, avidity and kinetics in immune recognition
- Prof. Anton van der Merwe
- Adaptive immunity T cells
-
31. The thymus and T cell development: a primer
- Prof. Georg Holländer
-
32. Lineage decisions in the thymus: T cell lineage commitment
- Prof. Bruno Silva-Santos
-
33. Lineage decisions in the thymus: αβ and γδ T cell lineages
- Prof. Bruno Silva-Santos
-
34. CD4 T cell subsets
- Dr. Brigitta Stockinger
-
35. Cytotoxic T lymphocytes
- Prof. Gillian Griffiths
-
36. Gamma delta T-cells
- Prof. Bruno Silva-Santos
-
37. Tfh and Tfr cells
- Prof. Luis Graca
-
38. Tissue resident memory T cells (TRM)
- Dr. Marc Veldhoen
-
39. Mathematical modeling in immunology
- Prof. Ruy M. Ribeiro
- The importance of the MHC in immunity
-
40. The MHC and MHC molecules 1
- Prof. Jim Kaufman
-
41. The MHC and MHC molecules 2
- Prof. Jim Kaufman
-
42. Natural killer cells
- Dr. Philippa Kennedy
-
44. NK cells in viral immunity
- Prof. Lewis Lanier
- Lymphocyte activation
-
45. Signal transduction by leukocyte receptors
- Dr. Omer Dushek
-
46. Immunological memory 1
- Prof. David Gray
-
47. Immunological memory 2
- Prof. David Gray
-
48. Studying immune responses “one cell at a time”
- Dr. Mir-Farzin Mashreghi
- Major cellular partners in immunity
-
49. The mononuclear phagocyte system - tissue resident macrophages: distribution and functions
- Prof. Emeritus Siamon Gordon
-
50. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation
- Prof. Emeritus Siamon Gordon
-
51. Dendritic cells: professional antigen presenting cells
- Prof. Paul J. Fairchild
-
52. Mucosal immunology
- Prof. Daniel Mucida
- Immunological tolerance and regulation
-
53. Self-tolerance
- Prof. Herman Waldmann
-
54. Tolerance and autoimmunity
- Prof. Emerita Anne Cooke
-
55. The balance between intestinal immune homeostasis and inflammation
- Prof. Dr. Janneke Samsom
- Translational immunology - immune deficiency
-
56. Primary immunodeficiency disorders
- Dr. Smita Y. Patel
-
57. Changes in innate and adaptive immunity during human ageing 1
- Dr. Roel De Maeyer
-
58. Changes in innate and adaptive immunity during human ageing 2
- Dr. Roel De Maeyer
-
59. The aging immune system
- Prof. Ana Caetano
- Translational immunology - protection against pathogenic microbes
-
60. Immune responses to viruses
- Prof. Paul Klenerman
-
61. HIV and the immune system
- Prof. Quentin Sattentau
-
62. COVID-19: the anti-viral immune response
- Prof. Danny Altmann
-
63. Bacterial immune evasion
- Prof. Christoph Tang
-
64. The immunology underlying tuberculosis
- Prof. Thomas R. Hawn
-
65. Innate immunity to fungi
- Prof. Gordon D. Brown
-
66. Parasite immunity: introduction and Plasmodium
- Dr. Catarina Gadelha
-
67. Parasite immunity: Leishmania and Schistosoma
- Dr. Catarina Gadelha
-
68. Vaccination
- Dr. Anita Milicic
-
69. The history of vaccines 1
- Prof. Emeritus Anthony R. Rees
-
70. The history of vaccines 2
- Prof. Emeritus Anthony R. Rees
-
71. The history of vaccines 3
- Prof. Emeritus Anthony R. Rees
-
72. The science of vaccine adjuvants
- Dr. Derek O'Hagan
- Translational immunology - hypersensitivity, autoimmune disease and their management
-
73. Hypersensitivity diseases: type 1 hypersensitivity
- Prof. Herman Waldmann
-
74. Innate lymphoid cells in allergy
- Prof. Emeritus Shigeo Koyasu
-
75. Hypersensitivity diseases: type II-IV hypersensitivity
- Prof. Sara Marshall
-
76. B cells at the crossroads of autoimmune diseases
- Dr. Xiang Lin
-
77. Interleukin-17: from clone to clinic
- Prof. Leonie Taams
-
78. Autoimmunity and type 1 diabetes
- Prof. Emerita Anne Cooke
-
79. What is new in type 1 diabetes?
- Prof. Åke Lernmark
-
80. Antibodies to control or prevent type 1 diabetes
- Dr. Robert Hilbrands
-
81. Monoclonal antibodies in haemato-oncology
- Prof. Mark Cragg
-
82. Therapeutic antibodies
- Dr. Geoffrey Hale
-
83. Neuroimmunometabolism
- Prof. Ana Domingos
-
84. The immunology of multiple sclerosis
- Dr. Joanne Jones
-
85. Understanding myasthenia gravis and advances in its management
- Prof. Henry J. Kaminski
-
86. The immunology underlying rheumatic diseases
- Dr. Hussein Al-Mossawi
-
88. Complement and lupus
- Prof. Marina Botto
-
89. Immune mechanisms in liver diseases
- Prof. Paul Klenerman
- Translational immunology - transplantation immunology
-
90. Principles of transplantation: overview of the immune response
- Prof. Emerita Kathryn Wood
-
91. Factors influencing outcomes in clinical transplantation 1
- Prof. Emerita Kathryn Wood
-
92. Factors influencing outcomes in clinical transplantation 2
- Prof. Emerita Kathryn Wood
- Translational immunology - cancer immunology
-
93. Cancer immunology
- Prof. Tim Elliott
-
94. Cancer immunotherapy
- Prof. Tim Elliott
-
95. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
-
96. IL-2 in the immunotherapy of autoimmunity and cancer
- Prof. Thomas Malek
-
97. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours
- Dr. Else Marit Inderberg
Printable Handouts
Navigable Slide Index
- Introduction
- Part II - interplay between cell death mechanisms and immunity
- Contents of the lecture: part II
- The crossroads of cell death and immunity
- Regulation of cell number
- Regulation of cell number in the thymus: basis of central tolerance
- Clonal restriction of lymphocytes in peripheral tissues
- Regulation of pathogen response (1)
- Regulation of cell death mediated by bacterial infection
- Regulation of pathogen response (2)
- Manipulation of cell death pathways mediated by viruses
- How cell death helps pathogen clearance: resolution phase
- Cell death and inflammation
- Induction of cell death within the Immune system: preferential routes
- Molecular factors employed by the immune system to induce cell death
- Autonomous and non-cell autonomous cell death mediated by ligand-receptor
- Cell death induced by membrane pore forming proteins and granzymes
- Cell death induced by the complement system
- Apoptosis induced by the complement system in mammalian cells
- Self-tolerance and immunogenecity (immunogenic cell death)
- Silent vs. immunogenic cell death
- Intracellular mechanisms > apoptosis favors self-tolerance
- Extracellular mechanisms > apoptosis favors self-tolerance
- Apoptosis favors self-tolerance and non-immunogenic death
- Explosive forms of death are highly immunogenic (1)
- Explosive forms of death are highly immunogenic (2)
- Immunogenic cell death and cancer therapy
- Route of chemotherapy driven ICD
- Conclusions part II
- Acknowledgements
Topics Covered
- Crosstalk between the RCD mechanisms and the immune response
- Immunological cell death vs. other forms of RCD
- Immune system factors that are involved in cell death
- Self-tolerance and immunogenicity
- Immunogenic cell death and cancer therapy
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Baena-Lopez, L.A. (2020, July 30). Regulated cell death mechanisms and their crosstalk with the immune system 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/4358/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Baena-Lopez has no commercial/financial relationships to disclose.
Regulated cell death mechanisms and their crosstalk with the immune system 2
Published on July 30, 2020
25 min
A selection of talks on Cell Biology
Transcript
Please wait while the transcript is being prepared...
0:00
Hello and welcome.
My name is Luis Alberto Baena-Lopez.
I'm a research scientist in the University of Oxford.
We will revise in this lecture
the main regulated forms of
cell death and the crosstalk that they have with the immune system.
0:16
Second part of the lecture;
interplay between cell death mechanisms and immunity.
0:22
Cell death can be considered an integral part of the immune response that guides
both the immune system and the tissue microenvironment to ensure tissue homeostasis,
tissue repair, and the fight against pathogens.
Therefore, failure of the cell death mechanisms can
severely compromise multiple features of the immune response.
Consequently, since the origin of autoimmune diseases,
defects in the defense against pathogens,
development of tumors, and neurological disorders.
This part of the lecture will provide an overview of the extensive intersection
between the cell death mechanisms and the immune system, including each regulation.
Also, through a series of selected examples,
we will illustrate the impact of cell death defects in the immune response,
and how either pathogens or faulty cells can hijack the cell death programs to thrive.
We will also show how defects in the activation of
cell death programs can lead to generated immune diseases or predisposition to infection.
As part of this, finally,
we will describe how adequate
cell death activation can be exploited to fight against the cancer.
1:27
As described before, cell death can influence many aspects of the immune response,
and cell death mechanisms have been shown to regulate the number of immune cells,
the response of the immune system against pathogens,
an inflammatory process and its resolution.
Also, the cell death mechanisms install self-tolerance.
Therefore, the way cells die is critical to avoid disposal of self-antigens.
Reciprocally, they are key to reveal antigens
that alert the immune system about the presence of faulty cells,
such as tumors and infected cells.
In this part of the lecture,
we will review the implication of
cell death mechanisms in different aspects of the immune response.
I will provide key examples that will illustrate
the fundamental role played by
the regulated cell death mechanisms during the immune response.
Hide