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- Introduction to Calcium Signaling
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1. Introduction to cellular calcium signaling
- Dr. Martin Bootman
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2. Monitoring Ca2+ concentration in living cells
- Dr. Marisa Brini
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3. Cell boundary theorem
- Prof. Eduardo Ríos
- Calcium Influx
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4. Arachidonic acid and store-independent Ca2+ entry
- Dr. Luca Munaron
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5. Voltage-dependent calcium channels
- Prof. Annette Dolphin
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7. Intracellular Ca2+ signaling: calcium influx
- Prof. Anant Parekh
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8. Molecular identification of the CRAC channel
- Prof. Michael Cahalan
- Calcium Release
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10. The InsP3 receptor calcium release channel
- Prof. J. Kevin Foskett
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11. Molecular biology of ryanodine receptors: an overview
- Dr. Christopher George
- Prof. F. Anthony Lai
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12. cADPR and NAADP: messengers for calcium signalling
- Prof. Antony Galione
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13. Ryanodine receptors and cardiac function
- Prof. David Eisner
- Calcium Efflux and Sequestration
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14. Sodium-calcium exchange
- Prof. John Reeves
- Organelle Calcium
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15. Regulation and role of mitochondrial Ca2+ homeostasis
- Prof. Rosario Rizzuto
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16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis
- Dr. Paola Pizzo
- Dr. Alex Costa
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17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum
- Dr. Wolfgang Graier
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18. Nuclear calcium signaling
- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
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19. Regulation of intracellular calcium signaling, localized signals and oscillations
- Prof. Barbara Ehrlich
- Calcium Effectors
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24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization
- Prof. Dermot Cooper
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25. Calcium and transcription-coupling
- Dr. Karen Lounsbury
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26. Cellular calcium (Ca2+) buffers
- Prof. Dr. Beat Schwaller
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27. Extracellular calcium signaling
- Dr. Aldebaran M. Hofer
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28. Ca2+, fertilization and egg activation
- Prof. Karl Swann
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29. Calcium regulation of transcription in plants
- Prof. Hillel Fromm
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30. Mechanisms regulating STIM expression and function in Ca2+ signaling
- Dr. Jonathan Soboloff
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31. Dynamic signal encoding in the S. cerevisiae calcium response
- Dr. Chiraj Dalal
- Calcium and Disease
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32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
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33. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
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34. Pancreatitis and calcium signaling
- Prof. Ole Petersen
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35. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
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36. Genetic defects and calcium
- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
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37. Calcium, calmodulin and calcineurin
- Prof. Stephen Bolsover
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38. Calcium flickers steer cell migration
- Prof. Heping Cheng
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39. Automated Ca2+ imaging of chemosensory neurones in C.elegans
- Dr. Nikos Chronis
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40. Ca2+ and the regulation of small GTPases
- Prof. Peter Cullen
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41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo
- Dr. Michael I. Kotlikoff
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42. Capacitative (store-operated) calcium entry
- Dr. Jim Putney
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43. The molecular biology of the inositol trisphosphate receptor
- Dr. Randen Patterson
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44. Coordinated Ca2+ release from intracellular Ca2+ stores
- Prof. Ole Petersen
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45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology
- Prof. Ernesto Carafoli
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46. The calcium saga: a matter of life and death
- Prof. Pierluigi Nicotera
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47. Ca2+ efflux and Ca2+ signals
- Dr. Anne Green
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50. Modeling Ca2+ signals
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Alzheimer's disease (AD)
- Neuropathological lesions associated with AD
- Neurofibrillary tangles
- Beta-amyloid plaques
- Alzheimer amyloid precursor protein (APP)
- APP is cleaved by alpha-secretase
- APP is cleaved by beta-secretase
- Cleavage by gamma-secretase
- Generation of A-beta-42
- Genetic studies
- Genetics of Alzheimer's disease
- APP mutations cluster around secretase sites
- Presenilin and its interactions
- Presenilin (PS1 and PS2)
- Presenilin functions
- FAD-associated presenilins mutations
- Calcium homeostasis
- PS and Ca2+ homeostasis
- FAD-PS1 potentiates calcium release
- Calcium signaling studies
- Ca2+ dyshomeostasis and Alzheimer's disease
- Presenilins have a physiological modulatory role
- A new PS function
- Two new FAD-linked PS2 mutations
- PS2 mutations: M239I and T122R
- FAD-linked PS2 mutations reduce Ca2+ release
- Other FAD linked mutations
- A genetically encoded luminescent Ca2+ sensor
- Effects of PS mutants on cytosolic Ca2+
- Cytosolic Ca2+ changes
- Effects on ER calcium content
- Effects on Golgi calcium content
- Mechanism(s)?
- PS2 mutants increase Ca2+ leak
- PS2 mutants inhibit SERCA pump
- PSs might be multi-functional proteins
- Discordance with the literature?
- An exaggerated Ca2+ response
- Exaggerated Ca2+ release hypothesis for AD
- Does PS affect mitochondria Ca2+ handling
- PS2 expression favors Ca2+ uptake
- PS2 increases ER-mitochondria interaction
- PS2 modulates ER-mitochondria tethering
- A reformulation of the Ca2+ hypothesis for FAD
- References
Topics Covered
- Introduction to Alzheimer's disease
- Morphological and functional features
- Genetic studies
- Presenilin functions and calcium homeostasis
- Calcium dyshomeostasis and FAD
- Modulatory role of presenilin on IP3-evoked Calcium release
- Different effects of PS mutants on intracellular Calcium stores
- A reformulation of the 'Calcium hypothesis' for FAD
Links
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Talk Citation
Pizzo, P. (2011, July 27). Ca2+ alterations in familial Alzheimer's disease (FAD) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/MWJJ2931.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Paola Pizzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.