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• 46 min
  1. Genetic defects and calcium

  • Prof. Tullio Pozzan
• 38 min
  2. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 28 min
  3. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 48 min
  4. Ca2+ signaling alterations in Alzheimer's disease

  • Dr. Grace Stutzmann
• 30 min
  5. Nociception and alpha2delta3

  • Dr. Greg Neely
• 45 min
  6. Disease hot spots of ryanodine receptors

  • Dr. Filip Van Petegem
• 46 min
  7. Calcium channelopathies

  • Dr. David Friel
• 27 min
  8. Ca2+, the endoplasmic reticulum and cardiac pathology

  • Prof. Marek Michalak
• 47 min
  9. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 49 min
  10. Store-operated Ca2+ entry and vascular smooth muscle remodeling

  • Prof. Mohamed Trebak
• 43 min
  11. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 21 min
  12. Acidocalcisomes: conserved from bacterial to human cells

  • Prof. Roberto Docampo
• 26 min
  13. Cellular signaling on host-malaria parasite interactions

  • Prof. Dr. Celia Regina da Silva Garcia
• 34 min
  14. Ca(v)1.3 and deafness

  • Dr. Amy Lee
• 38 min
  15. Immunodeficiencies and pathologies associated with mutations in STIM/ORAI

  • Dr. Thierry Capiod
• 31 min
  16. Vascular calcification location, formation and biological activity

  • Dr. Diane Proudfoot
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  17. Ca2+ channelopathies

  • Dr. David Friel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. The polycystic kidney disease (PKD)
4. Clinical aspects of ADPKD
5. Genetic aspects of ADPKD
6. PKD mutations are somatically recessive
7. The products of PKD1 and PKD2 : polycystins
8. Polycystin (1)
9. Polycystin (2)
10. Properties of the PC2 channel
11. PC1 and PC2: a receptor channel complex
12. Subcellular localization of PC1 and PC2
13. The PC1 and PC2 complex is conserved
14. Primary cilium and cystic kidney disease
15. Mechanosensory function of PC1/PC2 complex
16. PC1 and PC2 signaling
17. PC1, PC2 and calcium homeostasis
18. PC1, PC2 and calcium levels in kidney cells
19. PC1 and endoplasmic reticulum calcium uptake
20. PC1 tail expression and NFAT activation
21. PC1, cytoplasmic Ca levels and cell proliferation
22. PC1 expression and cell proliferation
23. Cross-talk between calcium and cAMP signaling
24. Polycystin calcium signaling

Topics Covered

• Clinical and genetic aspects of polycystic kidney disease
• The polycystins (PC1, PC2)
• The PC2 channel
• PC1 and PC2 subcellular location and interaction
• Mechanosensory function of the ciliary PC1/PC2 complex
• PC signaling and calcium homeostasis
• PC1, calcium levels and cell proliferation
• PC1, cAMP signaling and cell proliferation
• PCs and physiopathologic calcium signaling

Links

Series:

• Calcium Signaling I
• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Gastroenterology & Nephrology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Laura del Senno has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.