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- 2023
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1. Planning and response to COVID-19: lessons from China and South-East Asia
- Prof. Annelies Wilder-Smith
- 2022
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2. The emergence of the SARS-CoV-2 Omicron variant
- Prof. Emma Thomson
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3. How is Omicron different?
- Prof. Emma Thomson
- 2021
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5. Potential of ‘long-COVID’ in triggering chronic co-pathologies
- Dr. İmdat Eroğlu
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6. SARS-CoV-2 monoclonal antibody testing in vivo
- Prof. Michael Diamond
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7. mRNA COVID-19 vaccine efficacy in recovered vs COVID-naive individuals
- Prof. E. John Wherry
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8. SARS-CoV-2 variants: implications for immunity and vaccine development
- Prof. Danny Altmann
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10. SARS-COV-2 human monoclonal antibody therapy update
- Prof. James Crowe
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11. Emergence of blood clotting disorders resulting from COVID vaccines inoculations
- Prof. Dr. Sabine Eichinger
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12. SARS-CoV-2 evolution within and between individuals
- Prof. Katia Koelle
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13. Identifying SARS-CoV-2 proteases
- Prof. Dr. Christa E. Müller
- Prof. Dr. Michael Gütschow
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14. Genetic surveillance and the emergence of SARS-CoV-2 variants
- Prof. Emma Thomson
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15. The COVID-19 outbreak: April 2021 update
- Prof. Jonathan Temte
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16. ABO blood groups and SARS-CoV-2 susceptibility
- Dr. Sean Stowell
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17. Impact of COVID-19 on neuropsychiatric disorders and mental health
- Prof. Anthony David
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18. The immune system response to the SARS-CoV-2 virus: March 2021 update
- Prof. Paul Klenerman
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23. SARS-CoV-2 vaccine rollout campaigns
- Prof. Luis Graca
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25. Interspecies transmission of SARS-CoV-2
- Dr. Dalan Bailey
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26. Complement activation in COVID-19
- Prof. Jeffrey Laurence
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27. Human movement patterns and local spread of COVID-19
- Prof. Ben Cowling
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28. SARS-CoV-2 mutations: phenotypes and implications for vaccine development
- Prof. David Montefiori
- 2020
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29. The immune system response to the SARS-CoV-2 virus: December 2020 update
- Prof. Paul Klenerman
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30. Triage and end of life care planning in COVID-19
- Prof. Robin Taylor
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31. Natural killer cells as COVID-19 therapy
- Dr. Philippa Kennedy
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32. Update on the SNG001 drug, an INFβ therapy for COVID-19
- Prof. Stephen Holgate
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34. Identification of a new coronavirus-specific RNA export protein complex
- Dr. Montse Bárcena-Martin
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35. The neurological symptoms of COVID-19
- Dr. Michael Zandi
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36. Imperial College London’s saRNA Vaccine - COVAC1
- Dr. Katrina Pollock
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37. Interferon-α2b as a therapy for COVID-19
- Prof. Eleanor N. Fish
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38. Potential long-term health effects of a SARS-CoV-2 infection
- Prof. Danny Altmann
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39. The COVID-19 coronavirus outbreak: October 2020 update
- Prof. Jonathan Temte
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41. Rheumatic diseases and COVID-19
- Dr. Zachary Wallace
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42. The cardiovascular complications of SARS-CoV-2 infection
- Prof. Srihari Naidu
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43. Medical wearable devices for tracking symptoms of COVID-19
- Prof. John Rogers
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44. Risk of re-emergence of COVID-19 after exit from lockdown
- Dr. Leonardo Lopez
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45. The evolutionary origin of SARS-CoV-2
- Dr. Feng Gao
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46. Predicting COVID-19 outbreaks by measuring SARS-CoV-2 RNA in sewage sludge
- Prof. Jordan Peccia
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47. Approaches for elucidating genetic susceptibility to SARS-CoV-2
- Dr. Kenneth Baillie
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48. The immune system response to the SARS-CoV-2 virus: July 2020 update
- Prof. Paul Klenerman
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49. The impact of COVID-19 in the elderly and in care homes
- Dr. David Strain
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50. Human challenge trials for vaccines against COVID-19
- Prof. Peter Smith
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51. The development of SARS-CoV-2 vaccines
- Prof. Peter Hotez
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52. Convalescent plasma therapy as a treatment for COVID-19
- Dr. Manu Shankar-Hari
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53. Remdesivir COVID-19 clinical trial
- Prof. Mahesh Parmar
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54. Nanotechnologies in the fight against coronaviruses
- Prof. Sabine Szunerits
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55. The COVID-19 coronavirus outbreak: May 2020 update
- Prof. Jonathan Temte
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56. INFβ therapy for COVID-19: the new SNG001 drug
- Prof. Stephen Holgate
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57. Strategies for exiting the lockdown
- Prof. David McCoy
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58. SARS-CoV-2 human monoclonal antibody therapy
- Prof. James Crowe
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59. An FDA approved salivary test for SARS-CoV-2 infection
- Prof. Andrew Brooks
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60. Development of an intranasal vaccine for SARS-CoV-2
- Dr. Scot Roberts
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61. The immune system response to the SARS-CoV-2 virus: an update
- Prof. Paul Klenerman
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62. A novel AIOD-CRISPR system for diagnosis of SARS-CoV-2
- Prof. Changchun Liu
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63. Development of PRO-140 (Leronlimab) as a treatment for COVID-19
- Dr. Jacob Lalezari
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64. COVID-19 epidemiology and potential treatments: follow up interview
- Prof. Ralph Baric
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65. SARS-CoV-2 vaccine development: where are we now?
- Prof. Gary Kobinger
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66. SARS-CoV-2: What we need to know and possible future therapies
- Prof. Stanley Perlman
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67. SARS-CoV-2 vaccine: current biological targets and considerations
- Dr. Adolfo Garcia-Sastre
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68. The current understanding of the biology of the SARS-CoV-2 virus
- Prof. Peter Palese
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70. The immune system response to the SARS-CoV-2 virus
- Prof. Paul Klenerman
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71. SARS-CoV-2 vaccine development
- Prof. Stanley Plotkin
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72. The COVID-19 outbreak: an update on the SARS-CoV-2 virus
- Prof. Ralph Baric
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73. The COVID-19 coronavirus outbreak: a current view
- Prof. Jonathan Temte
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74. The COVID-19 coronavirus outbreak: March 2020 update
- Prof. Jonathan Temte
Topics Covered
- Current knowledge on the immune response to SARS-COV-2
- How the response to the novel virus is being studied
- The possibility of future health issues in infected individuals
- Future steps in the research into a COVID-19 infection
Biography
Paul Klenerman trained in medicine at Cambridge and Oxford and specialised in infectious diseases. He did his PhD in viral immunology at Oxford University and a postdoc in Zurich before returning to Oxford to establish a lab looking at immune responses to infection. The work includes studies of hepatitis C and a range of viruses affecting the lungs and liver - looking at how these evade the immune response, and the development of vaccines. He is focused especially on novel T cell responses in the mucosal surfaces which are critical for early host defence. He is an NIHR senior fellow and a Wellcome Trust investigator and holds a chair in the Nuffield Department of Medicine in Oxford.
Links
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Talk Citation
Klenerman, P. (2020, March 20). The immune system response to the SARS-CoV-2 virus [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/4218/.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Respiratory Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Interviewer: Professor Klenerman,
thank you for
recording this interview with
us on the very important topic
of how the immune system is fighting this
new coronavirus strain called SARS-CoV-2.
To start this interview, I'll ask you: how
does the immune system fight the usual
coronavirus strains, and
how is this new strain different?
Prof Klenerman: That's a good question
and I'll break it down into little bits.
The immune system has evolved to
fight viruses of any kind, and
coronaviruses and influenza and
other respiratory viruses are definitely
some of the things that have
driven our evolved immune system.
The first thing that happens when a virus
invades a cell is that you get something
called an 'innate response' to the virus,
and that's triggered by the ability
of the body to sense things that are
dangerous, things that shouldn't be there.
So there are components of the virus,
particularly the way it copies itself that
lead to structures that
are alien to normal cells,
and that is very sensitively
reacted to by the body so
a small amount of virus can
trigger a pretty brisk response.
That can happen quite quickly and
it puts all the cells in the location so,
say, the lining of the nose or the upper
airways onto some kind of alert, and
that has two effects, the first is that
the cells themselves can start to generate
mechanisms to fight off the virus, and
they can do that in a number of ways.
Essentially there's a massive
response within the cell,
particularly driven by a set of
small molecules called interferons,
which were discovered
about 60 years ago now.