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1. Introduction to biochemistry
- Prof. Gerald W. Feigenson
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2. Amino acids and peptides
- Prof. Gerald W. Feigenson
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3. Protein structure principles
- Prof. Gerald W. Feigenson
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4. Observed protein structures
- Prof. Gerald W. Feigenson
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5. Protein folds and IV structure
- Prof. Gerald W. Feigenson
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6. Protein stability and folding
- Prof. Gerald W. Feigenson
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7. Haemoglobin structure and stability
- Prof. Gerald W. Feigenson
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8. Enzyme specificity and catalysis
- Prof. Gerald W. Feigenson
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9. Enzyme kinetics (Michaelis-Menten)
- Prof. Gerald W. Feigenson
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10. Enzyme inhibition; chymotrypsin
- Prof. Gerald W. Feigenson
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11. Enzyme regulation and coenzymes
- Prof. Gerald W. Feigenson
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12. Lipids, biomembranes and membrane proteins
- Prof. Gerald W. Feigenson
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13. Structure and function of carbohydrates
- Prof. Gerald W. Feigenson
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14. Metabolism principles
- Prof. Gerald W. Feigenson
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15. Glycolysis - energy and useful cell chemicals
- Prof. Gerald W. Feigenson
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16. Glycolysis control
- Prof. Gerald W. Feigenson
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17. Metabolism of pyruvate and fat
- Prof. Gerald W. Feigenson
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18. Urea cycle; oxidative phosphorylation 1
- Prof. Gerald W. Feigenson
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19. Urea cycle; oxidative phosphorylation 2
- Prof. Gerald W. Feigenson
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20. Light-driven reactions in photosynthesis
- Prof. Gerald W. Feigenson
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21. Gluconeogenesis and the Calvin cycle
- Prof. Gerald W. Feigenson
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22. Synthesis of lipids and N-containing molecules 1
- Prof. Gerald W. Feigenson
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23. Synthesis of lipids and N-containing molecules 2
- Prof. Gerald W. Feigenson
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24. Hormone mechanisms
- Prof. Gerald W. Feigenson
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture overview
- Hormone action: 4 categories (1)
- Hormones that act via G-proteins
- Role of cAMP and the action of Protein Kinase A
- G-prot signalling via Phospholipase C & PI(4,5)P2
- Hormone action: 4 categories (2)
- Steroid hormone action
- Transient IV: many binding/interaction domains
- Insulin action inside the nucleus
- Insulin action in the cytosol
- Relevance of metabolic control to cancer
- How to think about the entire biochemistry subject
- Two main notes for biochemistry
- Main note for metabolism
- Professor's view of this biochemistry course
- Mind-boggling interconnections of metabolism
- Reflecting on biochemistry
- Lecture summary
Topics Covered
- Hormone action via G-protein
- Steroid hormone action in nucleus
- Insulin action in cytosol and nucleus
- Course summary
Talk Citation
Feigenson, G.W. (2022, November 27). Hormone mechanisms [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 5, 2024, from https://doi.org/10.69645/BLUW1750.Export Citation (RIS)
Publication History
Financial Disclosures
- Gerald Feigenson has no commercial/financial relationships to disclose.
Request access to the Principles of Biochemistry lecture series, an extensive introductory to the field of biochemistry. An HSTalks representative will contact you with more information about this series and getting unrestricted access to it.
A selection of talks on Biochemistry
Transcript
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0:00
Greetings. Welcome to this Principles of Biochemistry lecture series.
I am Jerry Feigenson,
a professor in the Department of Molecular Biology and Genetics
at Cornell University in the USA.
In the previous lecture,
you learned about synthesis of what we could call the most simple lipid, a fatty acid.
Then we saw synthesis of more complex phospholipids and fats.
And we examined cholesterol synthesis in cells. And also how
cholesterol reaches cells after it is packaged into lipoproteins in the liver.
Then we examined synthesis of many nitrogen containing molecules.
0:48
In this 22nd lecture,
the final lecture in this series,
you will learn about the different ways,
three or four different ways, that hormones act.
You will see that many hormones work by means of G-proteins.
You will see steroid hormones
that act in the nucleus. And insulin actions,
which are both in the cytosol and in the nucleus.
Then at the very end,
I will give a brief overview of this course.
1:22
So hormone action, we can identify four different categories.
The first category, and I will not talk too much about this one,
hormone activated ion channels.
For example, sodium, potassium,
calcium need ion channels,
and these can be hormone activated,
and once activated, the ions get into the cell.
The second category, and the third category,
are peptide or amine hormones that bind to receptors on the outside of cells,
and the action of both of these types is by the receptor,
not by hormone entry into the cell.
I will show you two different kinds of action, two different mechanisms.
In the first mechanism,
the hormone binds to the receptor,
and that receptor changes the transcription of messenger RNAs in the nucleus.
In the second kind of mechanism,
the hormone binds to the receptor and that causes changes in
cytosolic enzymes that already are preexisting in the cell,
but their activity is changed.
Then a fourth category of hormone action,
steroid or thyroid hormones
pass right through the plasma membrane and
usually then right through the nuclear membrane,
and they act on transcription in the nucleus.
That means they alter the amount of newly synthesized mRNA and newly synthesized protein.