Gene structure, expression and regulation: DNA structure and replication
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- Introduction to Calcium Signaling
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72 min
1. Introduction to cellular calcium signaling- Dr. Martin Bootman
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20 min
2. Monitoring Ca2+ concentration in living cells- Dr. Marisa Brini
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30 min
3. Cell boundary theorem- Prof. Eduardo Ríos
- Calcium Influx
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19 min
4. Arachidonic acid and store-independent Ca2+ entry- Dr. Luca Munaron
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34 min
5. Voltage-dependent calcium channels- Prof. Annette Dolphin
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34 min
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37 min
7. Intracellular Ca2+ signaling: calcium influx- Prof. Anant Parekh
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60 min
8. Molecular identification of the CRAC channel- Prof. Michael Cahalan
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35 min
- Calcium Release
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53 min
10. The InsP3 receptor calcium release channel- Prof. J. Kevin Foskett
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31 min
11. Molecular biology of ryanodine receptors: an overview- Dr. Christopher George
- Prof. F. Anthony Lai
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57 min
12. cADPR and NAADP: messengers for calcium signalling- Prof. Antony Galione
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43 min
13. Ryanodine receptors and cardiac function- Prof. David Eisner
- Calcium Efflux and Sequestration
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45 min
14. Sodium-calcium exchange- Prof. John Reeves
- Organelle Calcium
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42 min
15. Regulation and role of mitochondrial Ca2+ homeostasis- Prof. Rosario Rizzuto
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54 min
16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis- Dr. Paola Pizzo
- Dr. Alex Costa
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34 min
17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum- Dr. Wolfgang Graier
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26 min
18. Nuclear calcium signaling- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
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54 min
19. Regulation of intracellular calcium signaling, localized signals and oscillations- Prof. Barbara Ehrlich
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43 min
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41 min
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49 min
- Calcium Effectors
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34 min
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41 min
24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization- Prof. Dermot Cooper
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32 min
25. Calcium and transcription-coupling- Dr. Karen Lounsbury
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50 min
26. Cellular calcium (Ca2+) buffers- Prof. Dr. Beat Schwaller
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24 min
27. Extracellular calcium signaling- Dr. Aldebaran M. Hofer
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50 min
28. Ca2+, fertilization and egg activation- Prof. Karl Swann
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24 min
29. Calcium regulation of transcription in plants- Prof. Hillel Fromm
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34 min
30. Mechanisms regulating STIM expression and function in Ca2+ signaling- Dr. Jonathan Soboloff
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46 min
31. Dynamic signal encoding in the S. cerevisiae calcium response- Dr. Chiraj Dalal
- Calcium and Disease
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43 min
32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease- Prof. Laura del Senno
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28 min
33. Ca2+ alterations in familial Alzheimer's disease (FAD)- Dr. Paola Pizzo
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38 min
34. Pancreatitis and calcium signaling- Prof. Ole Petersen
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47 min
35. Mechanism-based therapies for heart failure and cardiac arrhythmias- Prof. Andrew Marks
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46 min
36. Genetic defects and calcium- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
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31 min
37. Calcium, calmodulin and calcineurin- Prof. Stephen Bolsover
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34 min
38. Calcium flickers steer cell migration- Prof. Heping Cheng
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28 min
39. Automated Ca2+ imaging of chemosensory neurones in C.elegans- Dr. Nikos Chronis
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46 min
40. Ca2+ and the regulation of small GTPases- Prof. Peter Cullen
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35 min
41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo- Dr. Michael I. Kotlikoff
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35 min
42. Capacitative (store-operated) calcium entry- Dr. Jim Putney
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47 min
43. The molecular biology of the inositol trisphosphate receptor- Dr. Randen Patterson
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50 min
44. Coordinated Ca2+ release from intracellular Ca2+ stores- Prof. Ole Petersen
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45 min
45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology- Prof. Ernesto Carafoli
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60 min
46. The calcium saga: a matter of life and death- Prof. Pierluigi Nicotera
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22 min
47. Ca2+ efflux and Ca2+ signals- Dr. Anne Green
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31 min
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58 min
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26 min
50. Modeling Ca2+ signals- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- The IP3 receptor
- Types of the IP3-R throughout the evolution
- mRNA isomers through the development
- Expansion of a gene: importance of function
- IP3-R isoforms potentially exist
- The expression of the IP3-R throughtout the cell
- Different IP3-R paralogs have different distributions
- Organelles in the cell
- IP3-R identified in the ER
- The IP3-R model
- Ankrin regulates channel activity and stability
- Chromagranins (Cg): Ca binding proteins
- The physiological link between the IP3-R and Cg
- Cg has an inhibitory effect on IP3-R function
- ERP44:IP3-R interaction
- Conditions in which ERP44 regulates IP3-R
- Proteins interaction with IP3-R lumenar regions
- CAM binding peptides
- CaBPs (calbindin): neuronal EF hand
- CaBPs interact with IP3-R
- RACK1 and the heterotrimeric G protein
- IP3-R:RACK1 interaction
- Human B-cells C825T mutation for G-beta-3
- IRBIT binds IP3-R near the IP3-R binding pocket
- IRBIT is sensitive to the IP3-R binding IP3
- Proteins interact with IP3-R: myosin, IRAG, CARP
- Myosin: IP3R modulate pharyngeal pumping
- CARP: carbonic anhydrase-related protein
- CARP binding sites in the IP3-R
- IRAG: IP3-R associated cyclic GMP kinase
- CGK1-beta
- The C-terminus of IP3-R
- Ca induced apoptosis and huntigton
- PP1A regulates IP3-R phosphorylation by PKA
- Mechanism for alterations: IP3-R phosphorylation
- IP3-R as a cytoskeletal element
- The 4.1N is critical for the basal-lateral targeting
- A multitude functional proteins interact with IP3-R
- IP3R in the Golgi apparatus
- Cg, Cam and CaBPs interact with IP3-R
- Sec 6/8 are active upstream of IP3 binding site
- IP3-R and plasma membrane interaction
- TRPC channels: Homer, Bank and Junctate
- The model for IP3R-TRPC interactions
- An Inhibitory effect of TRPC on IP3-R
- Are TRPC channels coupled to the IP3-R?
- The role of IP3-R in the TRPC activation
- Junctate protein interacts with IP3-R
- Junctate stimulates Ca release
- Proteins involved in the IP3R-TRPC complex
- BANK protein activity
- Proper Ca signaling
- IP3R affects the mitochondrial Ca homeostasis
- Apoptotic and nonapoptotic proteins
- IP3R is juxtaposed to mitochondria
- Ca overload is the key to cytochrome C release
- Caspase 3 and calpein in apoptosis
- Bcl and Bcl-xl: anti-apoptotic proteins
- Proteins interact with IP3-R during apoptosis
- The nucleus
- Nuclear Ca signals are induced by hepatocytic GF
- Why is IP3R located in the nucleus?
- IP3R in calciosomes
- Calciosomes
- Why are there 23,001 isomers of IP3R?
- IP3R isomers are necessary for function specificity
- Conclusions
Topics Covered
- Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3)
- The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions
- A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth
- The nodal properties of the IP3R and the mechanisms by which this occurs
Talk Citation
Patterson, R. (2007, October 1). The molecular biology of the inositol trisphosphate receptor [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/DOFE8213.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Randen Patterson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
