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1. Introduction
2. Importance of intracellular [Ca]
3. Ca is a life or death signal
4. Calcuim concentration controls may processes
5. The calcium specificity problem
6. Calcium specificity problem - explanations
7. Shape/kinetics of a Ca signal
8. Calcium distribution
9. Consequense of electrochemical Ca gradient
10. Plasma membrane permeability to Ca
11. Calcium entry channels
12. The two major Ca-selective channels
13. Techniques to study Ca channels
14. Voltage-operated Ca channels - VOCC
15. VOCC characteristics
16. Subtypes of VOCC
17. Evidence for sub-types of VOCC
18. VOCC - biophysics - current-voltage relationship
19. VOCC - biophysics - rate of inactivation
20. VOCC - biophysics - single channel conductance
21. VOCC - pharmacology
22. VOCC - molecular biology
23. Structure of VOCC
24. Beta subunit effects on inactivation
25. Topology of VOCC
26. Analysis of the primary amino acid sequence
27. Why are there so many VOCCs?
28. Not all VOCCs add to neurotransmitter release
29. Developmental changes in VOCC function
30. Ca-dependent gene expression
31. Non-channel functions of VOCC
32. Signal transduction
33. Anchoring protein
34. Store-operated channels: SOC
35. SOC: activated by store depletion
36. Store depletion under physiological conditions
37. CRAC channels
38. CRAC channels - non-excitable cells
39. Features of Ca current through CRAC channels
40. Properties of I-CRAC
41. I-CRAC - very selective for Ca
42. Information conveyed from stores to channels
43. Model: Ca release opens CRAC channels
44. Key point
45. Key signal - calcium sensor within the stores
46. Vesicular fusion model
47. Conformational coupling model
48. Diffusible messenger model
49. Stromal interaction molecule - STIM
50. Some unresolved questions on SOC

Topics Covered

• Importance of intracellular calcium in cell activation
• Sources of intracellular calcium
• Key role for calcium channels in the plasma membrane
• Voltageoperated calcium channels
• Sub-types of voltage-operated calcium channels
• Structure of voltage-operated calcium channels
• Functions of voltage-operated calcium channels
• Local calcium signals drive cellular responses
• Store-operated calcium channels
• Properties of store-operated channels
• CRAC channels
• Gating of CRAC channels

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Anant Parekh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.