• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 53 min
  10. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  11. Molecular biology of ryanodine receptors: an overview

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  12. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 43 min
  13. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  14. Sodium-calcium exchange

  • Prof. John Reeves
• Organelle Calcium
• 42 min
  15. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 34 min
  17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  18. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 54 min
  19. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 43 min
  20. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells: introduction and basic concepts

  • Dr. David Friel
• 41 min
  21. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: endoplasmic reticulum, calcium oscillations

  • Dr. David Friel
• 49 min
  22. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: mitochondria, models of spatially non-uniform Ca2+ signals, applications to analysis of experimental results

  • Dr. David Friel
• Calcium Effectors
• 34 min
  23. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  25. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  26. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  27. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  28. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  29. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  30. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  31. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  33. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  34. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  35. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  36. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  37. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  38. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  39. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  40. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  42. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney
• 47 min
  43. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 50 min
  44. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 45 min
  45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  46. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 22 min
  47. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• 31 min
  48. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 58 min
  49. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 26 min
  50. Modeling Ca2+ signals

  • Dr. David Friel

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Agonist-activated calcium entry
3. Store vs. non-store operated calcium channels
4. Arachidonic acid (AA) metabolism
5. Identity of AA-activated calcium channels
6. The first Arachidonic acid model
7. Angiogenesis and calcium signaling
8. Proangiogenic factor bFGF triggers calcium entry
9. Activation of tyrosine kinase receptors - effects
10. Proangiogenic calcium entry is mediated by AA
11. Different channels are involved in calcium entry
12. The Arachidonic acid model in endothelial cells
13. Nitric oxide
14. Nitric oxide's role in proangiogenic calcium entry
15. AA, NO release and calcium entry relations
16. The Arachidonic acid model is more complex
17. Biological roles of AA-activated calcium entry
18. AA- & NO-induced Ca2+ entry affects proliferation
19. CAI is an antiangiogenic compound in vivo
20. AA and tumor angiogenesis
21. ECs derived from human breast carcinoma (BTEC)
22. AA promotes BTEC tubulogenesis in vitro
23. CAI reduces AA-induced BTECs tubulogenesis
24. BTEC organization in capillary-like structures
25. Multiple roles for protein kinase A (PKA)
26. In BTECs NO is involved in calcium signaling
27. Another increase in signaling complexity
28. Differences between normal & tumor-derived ECs
29. Conclusions
30. Open questions
31. Laboratory of cellular and molecular angiogenesis

Topics Covered

• Agonist-activated calcium entry: different modes
• Synthesis and metabolism of arachidonic acid (AA)
• Properties of AA-activated calcium channels
• Other effects of AA on calcium homeostasis
• Calcium entry and cell proliferation
• AA as a critical mediator of mitogen-activated calcium entry in fibroblasts
• Role of AA-dependent calcium entry in endothelial cell proliferation and angiogenesis
• Nitric oxide, calcium entry and angiogenesis
• Regulation of proangiogenic calcium signals: a complex picture

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on August 16, 2011

Financial Disclosures

• Dr. Luca Munaron has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.